抗人 PSME2 抗体对
01AB01565
Proteasome activator subunit 2 (PSME2), also known as PA28β, is a crucial component of the immunoproteasome, a specialized form of the proteasome involved in processing viral and tumor antigens for presentation by MHC class I molecules, thus playing a vital role in immune surveillance. Structurally, PSME2 forms part of the 11S regulator complex, consisting of heterohexameric rings of alpha and beta subunits, which bind to the 20S proteasome core to induce conformational changes that modulate substrate entry and proteolytic activity. This modulator function extends to interactions that can suppress chymotrypsin-like activity independently of the 26S proteasome. Dysregulation of PSME2 expression has been linked to various cancers; downregulation correlates with increased invasiveness in gastric adenocarcinoma and esophageal squamous cell carcinoma. In contrast, PSME2 acts as a tumor suppressor in breast cancer and osteosarcoma, highlighting its potential as a prognostic marker and therapeutic target. Additionally, PSME2's circadian regulation suggests roles in cellular proteostasis and oxidative stress response that may influence aging and disease.
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技术参数
- 靶点基因名
- PSME2
- 蛋白别名
- proteasome activator subunit 2; PSME2
- UniProt
- Q9UL46
- 物种
- Human
产品详情
- 靶点名称
- PSME2
- 蛋白名称
- proteasome activator subunit 2
- 蛋白别名
- Proteasome activator complex subunit 2; 11S regulator complex subunit beta; REG-beta; Activator of multicatalytic protease subunit 2; Proteasome activator 28 subunit beta; PA28b; PA28beta
- 靶点基因名
- PSME2
- UniProt
- Q9UL46
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proteasome activator subunit 2 (PSME2), also known as PA28β, is a crucial component of the immunoproteasome, a specialized form of the proteasome involved in processing viral and tumor antigens for presentation by MHC class I molecules, thus playing a vital role in immune surveillance. Structurally, PSME2 forms part of the 11S regulator complex, consisting of heterohexameric rings of alpha and beta subunits, which bind to the 20S proteasome core to induce conformational changes that modulate substrate entry and proteolytic activity. This modulator function extends to interactions that can suppress chymotrypsin-like activity independently of the 26S proteasome. Dysregulation of PSME2 expression has been linked to various cancers; downregulation correlates with increased invasiveness in gastric adenocarcinoma and esophageal squamous cell carcinoma. In contrast, PSME2 acts as a tumor suppressor in breast cancer and osteosarcoma, highlighting its potential as a prognostic marker and therapeutic target. Additionally, PSME2's circadian regulation suggests roles in cellular proteostasis and oxidative stress response that may influence aging and disease.