抗人 PSMB6 抗体对
01AB00908
Proteasome 20S subunit beta 6 (PSMB6) is a crucial component of the 20S core proteasome complex, which is responsible for the proteolytic degradation of most intracellular proteins. This 22 kDa protein, encoded by the PSMB6 gene on chromosome 17p13.2, is part of the proteasome B-type family and exhibits caspase-like activity, cleaving after acidic residues. PSMB6 contributes to the assembly of the proteolytic chamber within the 20S proteasome, playing a vital role in protein quality control and regulation of various cellular processes. In the immune system, PSMB6 can be replaced by the inducible subunit PSMB9 to form the immunoproteasome, enhancing antigen processing. Dysregulation of PSMB6 has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer, making it a potential target for therapeutic interventions.
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技术参数
- 靶点基因名
- PSMB6
- 基因别名
- LMPY; Y
- 蛋白别名
- proteasome 20S subunit beta 6; PSMB6
- UniProt
- P28072
- 物种
- Human
产品详情
- 靶点名称
- PSMB6
- 蛋白名称
- proteasome 20S subunit beta 6
- 蛋白别名
- Proteasome subunit beta type-6; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome delta chain; Proteasome subunit Y
- 靶点基因名
- PSMB6
- 基因别名
- LMPY; Y
- UniProt
- P28072
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proteasome 20S subunit beta 6 (PSMB6) is a crucial component of the 20S core proteasome complex, which is responsible for the proteolytic degradation of most intracellular proteins. This 22 kDa protein, encoded by the PSMB6 gene on chromosome 17p13.2, is part of the proteasome B-type family and exhibits caspase-like activity, cleaving after acidic residues. PSMB6 contributes to the assembly of the proteolytic chamber within the 20S proteasome, playing a vital role in protein quality control and regulation of various cellular processes. In the immune system, PSMB6 can be replaced by the inducible subunit PSMB9 to form the immunoproteasome, enhancing antigen processing. Dysregulation of PSMB6 has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer, making it a potential target for therapeutic interventions.