人 PSMA6 抗体对
01AB01315
Proteasome 20S subunit alpha 6 (PSMA6) is a 27 kDa protein composed of 246 amino acids and encoded by the PSMA6 gene located at chromosome 14q13. As one of the seven alpha subunits forming the outer rings of the barrel-shaped 20S proteasome core, PSMA6 is essential for the assembly and function of the proteasome complex, which is responsible for the ATP/ubiquitin-dependent degradation of most intracellular proteins, maintaining protein homeostasis by removing misfolded, damaged, or regulatory proteins. The 20S core can associate with regulatory particles such as 19S, PA200, or PA28, enabling both ubiquitin-dependent and -independent proteolysis, which is crucial in processes like antigen presentation and spermatogenesis. Clinically, PSMA6 expression is upregulated in certain diseases, including breast cancer and viral hepatitis, suggesting a role in disease progression and immune regulation, with higher expression observed in tumor tissues compared to normal tissues.
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技术参数
- 靶点基因名
- PSMA6
- 基因别名
- PROS27
- 蛋白别名
- proteasome 20S subunit alpha 6; PSMA6
- UniProt
- P60900
- 物种
- Human
产品详情
- 靶点名称
- PSMA6
- 蛋白名称
- proteasome 20S subunit alpha 6
- 蛋白别名
- Proteasome subunit alpha type-6; 27 kDa prosomal protein; PROS-27; p27K; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chain
- 靶点基因名
- PSMA6
- 基因别名
- PROS27
- UniProt
- P60900
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proteasome 20S subunit alpha 6 (PSMA6) is a 27 kDa protein composed of 246 amino acids and encoded by the PSMA6 gene located at chromosome 14q13. As one of the seven alpha subunits forming the outer rings of the barrel-shaped 20S proteasome core, PSMA6 is essential for the assembly and function of the proteasome complex, which is responsible for the ATP/ubiquitin-dependent degradation of most intracellular proteins, maintaining protein homeostasis by removing misfolded, damaged, or regulatory proteins. The 20S core can associate with regulatory particles such as 19S, PA200, or PA28, enabling both ubiquitin-dependent and -independent proteolysis, which is crucial in processes like antigen presentation and spermatogenesis. Clinically, PSMA6 expression is upregulated in certain diseases, including breast cancer and viral hepatitis, suggesting a role in disease progression and immune regulation, with higher expression observed in tumor tissues compared to normal tissues.