人 PSMA3 抗体对
01AB01311
Proteasome 20S subunit alpha 3 (PSMA3) is a crucial component of the 20S core proteasome complex, responsible for the proteolytic degradation of most intracellular proteins. This 28.4 kDa protein, composed of 254 amino acids, contributes to the formation of heptameric alpha rings and the substrate entrance gate. PSMA3 plays a vital role in protein quality control, regulatory protein degradation, and antigen processing for MHC class I presentation. It interacts with various regulatory particles to form the 26S proteasome, which degrades ubiquitinated proteins in an ATP-dependent manner. In terms of disease associations, PSMA3 has been implicated in cancer progression, particularly in esophageal squamous cell carcinoma (ESCC). Abnormal expression of PSMA3 is linked to cancer stemness and immunomodulation, with studies showing its involvement in suppressing CD8+ T-cell infiltration through regulation of chemokine CCL3.
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技术参数
- 靶点基因名
- PSMA3
- 基因别名
- HC8; PSC8
- 蛋白别名
- proteasome 20S subunit alpha 3; PSMA3
- UniProt
- P25788
- 物种
- Human
产品详情
- 靶点名称
- PSMA3
- 蛋白名称
- proteasome 20S subunit alpha 3
- 蛋白别名
- Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8
- 靶点基因名
- PSMA3
- 基因别名
- HC8; PSC8
- UniProt
- P25788
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proteasome 20S subunit alpha 3 (PSMA3) is a crucial component of the 20S core proteasome complex, responsible for the proteolytic degradation of most intracellular proteins. This 28.4 kDa protein, composed of 254 amino acids, contributes to the formation of heptameric alpha rings and the substrate entrance gate. PSMA3 plays a vital role in protein quality control, regulatory protein degradation, and antigen processing for MHC class I presentation. It interacts with various regulatory particles to form the 26S proteasome, which degrades ubiquitinated proteins in an ATP-dependent manner. In terms of disease associations, PSMA3 has been implicated in cancer progression, particularly in esophageal squamous cell carcinoma (ESCC). Abnormal expression of PSMA3 is linked to cancer stemness and immunomodulation, with studies showing its involvement in suppressing CD8+ T-cell infiltration through regulation of chemokine CCL3.