人 PSMA2 抗体对
01AB01310
Proteasome 20S subunit alpha 2 (PSMA2), is a critical alpha subunit of the 20S proteasome core complex, which forms a barrel-shaped structure composed of four stacked rings-two outer alpha rings and two inner beta rings-totaling 28 subunits. PSMA2 contributes to the assembly and structural integrity of the proteasome, which performs ATP/ubiquitin-dependent proteolysis of damaged or regulatory proteins, maintaining cellular protein homeostasis. The proteasome’s proteolytic activities include chymotrypsin-like, trypsin-like, and caspase-like cleavages, essential for protein quality control and immune surveillance. PSMA2 is upregulated in oral squamous cell carcinoma (OSCC), where it promotes tumorigenesis, chemo- and radioresistance by regulating cell cycle progression, mitochondrial dysfunction, and mitophagy pathways. Additionally, PSMA2 is exploited by influenza A virus to evade immune clearance and is associated with immune response modulation in cancers.
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技术参数
- 靶点基因名
- PSMA2
- 基因别名
- HC3; PSC3
- 蛋白别名
- proteasome 20S subunit alpha 2; PSMA2
- UniProt
- P25787
- 物种
- Human
产品详情
- 靶点名称
- PSMA2
- 蛋白名称
- proteasome 20S subunit alpha 2
- 蛋白别名
- Proteasome subunit alpha type-2; Macropain subunit C3; Multicatalytic endopeptidase complex subunit C3; Proteasome component C3
- 靶点基因名
- PSMA2
- 基因别名
- HC3; PSC3
- UniProt
- P25787
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proteasome 20S subunit alpha 2 (PSMA2), is a critical alpha subunit of the 20S proteasome core complex, which forms a barrel-shaped structure composed of four stacked rings-two outer alpha rings and two inner beta rings-totaling 28 subunits. PSMA2 contributes to the assembly and structural integrity of the proteasome, which performs ATP/ubiquitin-dependent proteolysis of damaged or regulatory proteins, maintaining cellular protein homeostasis. The proteasome’s proteolytic activities include chymotrypsin-like, trypsin-like, and caspase-like cleavages, essential for protein quality control and immune surveillance. PSMA2 is upregulated in oral squamous cell carcinoma (OSCC), where it promotes tumorigenesis, chemo- and radioresistance by regulating cell cycle progression, mitochondrial dysfunction, and mitophagy pathways. Additionally, PSMA2 is exploited by influenza A virus to evade immune clearance and is associated with immune response modulation in cancers.