人 PSMA1 抗体对
01AB00361
Proteasome 20S subunit alpha 1 (PSMA1) is a protein encoded by the PSMA1 gene in humans. It is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex, which is crucial for the degradation of intracellular proteins. The 20S proteasome is composed of four stacked rings, two alpha and two beta rings, with the beta rings forming a proteolytic chamber and the alpha rings forming the entrance for substrates. PSMA1, also known as proteasome subunit alpha type-1, encodes the α6 subunit that makes up the outer ring of the 20S core particle. This protein plays a significant role in various biological processes, including protein quality control and the processing of class I MHC peptides. In disease contexts, PSMA1 has been implicated in tumor progression and poor prognosis in gastric carcinoma by deubiquitinating and stabilizing TAZ.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- PSMA1
- 基因别名
- HC2; NU; PROS30; PSC2
- 蛋白别名
- proteasome 20S subunit alpha 1; PSMA1
- UniProt
- P25786
- 物种
- Human
产品详情
- 靶点名称
- PSMA1
- 蛋白名称
- proteasome 20S subunit alpha 1
- 蛋白别名
- Proteasome subunit alpha type-1; 30 kDa prosomal protein; PROS-30; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chain
- 靶点基因名
- PSMA1
- 基因别名
- HC2; NU; PROS30; PSC2
- UniProt
- P25786
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proteasome 20S subunit alpha 1 (PSMA1) is a protein encoded by the PSMA1 gene in humans. It is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex, which is crucial for the degradation of intracellular proteins. The 20S proteasome is composed of four stacked rings, two alpha and two beta rings, with the beta rings forming a proteolytic chamber and the alpha rings forming the entrance for substrates. PSMA1, also known as proteasome subunit alpha type-1, encodes the α6 subunit that makes up the outer ring of the 20S core particle. This protein plays a significant role in various biological processes, including protein quality control and the processing of class I MHC peptides. In disease contexts, PSMA1 has been implicated in tumor progression and poor prognosis in gastric carcinoma by deubiquitinating and stabilizing TAZ.