抗人 PSIP1 抗体对
01AB03357
PC4 and SRSF1 interacting protein 1 (PSIP1), also known as LEDGF/p75, is a chromatin-associated protein that functions as a transcriptional coactivator and epigenetic reader. Through its PWWP domain, it binds H3K36-methylated nucleosomes to tether protein complexes to transcriptionally active chromatin. Notably, PSIP1 recruits HIV-1 integrase to host chromatin, facilitating viral integration into active genes. It also plays a key role in stress responses as a cofactor for HSF1. In pathology, PSIP1 is implicated in MLL-rearranged leukemias, where it stabilizes oncogenic fusion proteins, and contributes to cancer progression and therapy resistance through transcriptional reprogramming.
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技术参数
- 靶点基因名
- PSIP1
- 基因别名
- DFS70; LEDGF; PSIP2
- 蛋白别名
- PC4 and SRSF1 interacting protein 1; PSIP1
- UniProt
- O75475
- 物种
- Human
产品详情
- 靶点名称
- PSIP1
- 蛋白名称
- PC4 and SRSF1 interacting protein 1
- 蛋白别名
- PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52
- 靶点基因名
- PSIP1
- 基因别名
- DFS70; LEDGF; PSIP2
- UniProt
- O75475
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
PC4 and SRSF1 interacting protein 1 (PSIP1), also known as LEDGF/p75, is a chromatin-associated protein that functions as a transcriptional coactivator and epigenetic reader. Through its PWWP domain, it binds H3K36-methylated nucleosomes to tether protein complexes to transcriptionally active chromatin. Notably, PSIP1 recruits HIV-1 integrase to host chromatin, facilitating viral integration into active genes. It also plays a key role in stress responses as a cofactor for HSF1. In pathology, PSIP1 is implicated in MLL-rearranged leukemias, where it stabilizes oncogenic fusion proteins, and contributes to cancer progression and therapy resistance through transcriptional reprogramming.