人 PSGL1 抗体对
01AB03019
Selectin P ligand (PSGL1), or CD162, is a mucin-like type I transmembrane glycoprotein expressed on the surface of most leukocytes and platelets. As a homodimer, it serves as the high-affinity ligand for P-, E-, and L-selectins, mediating the initial tethering and rolling of leukocytes on activated endothelium during inflammation. This interaction is dependent on specific post-translational modifications, including tyrosine sulfation and sialyl Lewis x glycosylation. Beyond cell adhesion, PSGL-1 functions as a signaling receptor that regulates immune cell activation and cytoskeletal polarization. Dysregulation of PSGL-1 is implicated in inflammatory and thrombotic disorders, and it also exhibits intrinsic antiviral activity against pathogens like HIV-1.
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技术参数
- 靶点基因名
- SELPLG
- 蛋白别名
- selectin P ligand; PSGL1
- UniProt
- Q14242
- 物种
- Human
产品详情
- 靶点名称
- PSGL1
- 蛋白名称
- selectin P ligand
- 蛋白别名
- P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD antigen CD162
- 靶点基因名
- SELPLG
- UniProt
- Q14242
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Selectin P ligand (PSGL1), or CD162, is a mucin-like type I transmembrane glycoprotein expressed on the surface of most leukocytes and platelets. As a homodimer, it serves as the high-affinity ligand for P-, E-, and L-selectins, mediating the initial tethering and rolling of leukocytes on activated endothelium during inflammation. This interaction is dependent on specific post-translational modifications, including tyrosine sulfation and sialyl Lewis x glycosylation. Beyond cell adhesion, PSGL-1 functions as a signaling receptor that regulates immune cell activation and cytoskeletal polarization. Dysregulation of PSGL-1 is implicated in inflammatory and thrombotic disorders, and it also exhibits intrinsic antiviral activity against pathogens like HIV-1.