人 PSD95 抗体对
01AB03205
Discs large MAGUK scaffold protein 4 (DLG4), commonly known as PSD-95, is a major scaffolding protein of the postsynaptic density in glutamatergic neurons. It organizes the synaptic architecture by clustering NMDA and AMPA receptors, along with adhesion molecules like neuroligins, via its PDZ, SH3, and guanylate kinase-like domains. PSD-95 is fundamental to synaptic plasticity and transmission strength. Dysregulation of DLG4 is strongly implicated in neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. Alterations in its expression or function disrupt synaptic circuitry and spine morphology, contributing to cognitive dysfunction and behavioral abnormalities.
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技术参数
- 靶点基因名
- DLG4
- 基因别名
- PSD95
- 蛋白别名
- discs large MAGUK scaffold protein 4; PSD95
- UniProt
- P78352
- 物种
- Human
产品详情
- 靶点名称
- PSD95
- 蛋白名称
- discs large MAGUK scaffold protein 4
- 蛋白别名
- Disks large homolog 4; Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90
- 靶点基因名
- DLG4
- 基因别名
- PSD95
- UniProt
- P78352
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Discs large MAGUK scaffold protein 4 (DLG4), commonly known as PSD-95, is a major scaffolding protein of the postsynaptic density in glutamatergic neurons. It organizes the synaptic architecture by clustering NMDA and AMPA receptors, along with adhesion molecules like neuroligins, via its PDZ, SH3, and guanylate kinase-like domains. PSD-95 is fundamental to synaptic plasticity and transmission strength. Dysregulation of DLG4 is strongly implicated in neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. Alterations in its expression or function disrupt synaptic circuitry and spine morphology, contributing to cognitive dysfunction and behavioral abnormalities.