人 PRSS27 抗体对
01AB01305
Serine protease 27 (PRSS27), also known as pancreasin, is a secreted tryptic serine protease belonging to the group-1 subfamily of serine proteases and is primarily expressed in the pancreas. The protein is encoded by the PRSS27 gene located within a large protease gene cluster on chromosome 16 and undergoes alternative splicing, resulting in multiple transcript variants. Structurally, PRSS27 is a glycosylated protein with a molecular weight of approximately 30.9 kDa, featuring a signal peptide, propeptide, and mature chain, and contains disulfide bonds critical for its stability and function. Functionally, it is involved in proteolytic processes, and its enzymatic activity is dependent on a conserved serine residue in the active site. Clinically, altered expression of PRSS27 has been identified as a prognostic marker in esophageal squamous cell carcinoma, particularly in patients treated with preoperative chemotherapy.
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技术参数
- 靶点基因名
- PRSS27
- 基因别名
- MPN
- 蛋白别名
- serine protease 27; PRSS27
- UniProt
- Q9BQR3
- 物种
- Human
产品详情
- 靶点名称
- PRSS27
- 蛋白名称
- serine protease 27
- 蛋白别名
- Serine protease 27; Marapsin; Pancreasin
- 靶点基因名
- PRSS27
- 基因别名
- MPN
- UniProt
- Q9BQR3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Serine protease 27 (PRSS27), also known as pancreasin, is a secreted tryptic serine protease belonging to the group-1 subfamily of serine proteases and is primarily expressed in the pancreas. The protein is encoded by the PRSS27 gene located within a large protease gene cluster on chromosome 16 and undergoes alternative splicing, resulting in multiple transcript variants. Structurally, PRSS27 is a glycosylated protein with a molecular weight of approximately 30.9 kDa, featuring a signal peptide, propeptide, and mature chain, and contains disulfide bonds critical for its stability and function. Functionally, it is involved in proteolytic processes, and its enzymatic activity is dependent on a conserved serine residue in the active site. Clinically, altered expression of PRSS27 has been identified as a prognostic marker in esophageal squamous cell carcinoma, particularly in patients treated with preoperative chemotherapy.