人 PRSS22 抗体对
01AB02683
Serine protease 22 (PRSS22), also known as brain-specific serine protease 4 or tryptase epsilon, is a secreted trypsin-like serine endopeptidase belonging to the S1 family. It is primarily expressed in the airway epithelium and other tissues such as the esophagus and pancreas, where it contributes to proteolysis and extracellular matrix remodeling. PRSS22 exhibits serine-type endopeptidase and peptidase activator activities, influencing signaling pathways including PI3K and p53. Clinically, PRSS22 is significantly dysregulated in various malignancies, particularly colorectal cancer, where its upregulation in primary tumors and lymph nodes serves as a prognostic biomarker for recurrence and reduced survival. Its involvement in tumorigenesis and immune microenvironment modulation makes it a potential therapeutic target.
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技术参数
- 靶点基因名
- PRSS22
- 基因别名
- BSSP4; PRSS26
- 蛋白别名
- serine protease 22; PRSS22
- UniProt
- Q9GZN4
- 物种
- Human
产品详情
- 靶点名称
- PRSS22
- 蛋白名称
- serine protease 22
- 蛋白别名
- Brain-specific serine protease 4; BSSP-4; Serine protease 22; Serine protease 26; Tryptase epsilon
- 靶点基因名
- PRSS22
- 基因别名
- BSSP4; PRSS26
- UniProt
- Q9GZN4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Serine protease 22 (PRSS22), also known as brain-specific serine protease 4 or tryptase epsilon, is a secreted trypsin-like serine endopeptidase belonging to the S1 family. It is primarily expressed in the airway epithelium and other tissues such as the esophagus and pancreas, where it contributes to proteolysis and extracellular matrix remodeling. PRSS22 exhibits serine-type endopeptidase and peptidase activator activities, influencing signaling pathways including PI3K and p53. Clinically, PRSS22 is significantly dysregulated in various malignancies, particularly colorectal cancer, where its upregulation in primary tumors and lymph nodes serves as a prognostic biomarker for recurrence and reduced survival. Its involvement in tumorigenesis and immune microenvironment modulation makes it a potential therapeutic target.