人前列腺分泌蛋白抗体对
01AB01759
Microseminoprotein beta (Prostate Secretory Protein), also known as MSMB, is a small, disulfide-bonded protein and one of the most abundant components of human seminal fluid. Produced by prostate epithelial cells, MSMB functions as a regulator of epithelial growth and apoptosis through mechanisms independent of androgen control. Clinically, MSMB is a significant biomarker and tumor suppressor in prostate disease. Its expression is typically high in healthy prostate tissue but is frequently lost or significantly reduced in prostate cancer, with lower levels correlating with higher Gleason grades and advanced disease progression. Furthermore, a well-characterized promoter variant (rs10993994) is strongly associated with an increased risk of developing prostate cancer and reduced circulating MSMB levels, establishing its importance in oncology.
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技术参数
- 靶点基因名
- MSMB
- 基因别名
- PRSP
- 蛋白别名
- microseminoprotein beta; Prostate Secretory Protein
- UniProt
- P08118
- 物种
- Human
产品详情
- 靶点名称
- Prostate Secretory Protein
- 蛋白名称
- microseminoprotein beta
- 蛋白别名
- Beta-microseminoprotein; Immunoglobulin-binding factor; IGBF; PN44; Prostate secreted seminal plasma protein; Prostate secretory protein of 94 amino acids; PSP-94; PSP94; Seminal plasma beta-inhibin
- 靶点基因名
- MSMB
- 基因别名
- PRSP
- UniProt
- P08118
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Microseminoprotein beta (Prostate Secretory Protein), also known as MSMB, is a small, disulfide-bonded protein and one of the most abundant components of human seminal fluid. Produced by prostate epithelial cells, MSMB functions as a regulator of epithelial growth and apoptosis through mechanisms independent of androgen control. Clinically, MSMB is a significant biomarker and tumor suppressor in prostate disease. Its expression is typically high in healthy prostate tissue but is frequently lost or significantly reduced in prostate cancer, with lower levels correlating with higher Gleason grades and advanced disease progression. Furthermore, a well-characterized promoter variant (rs10993994) is strongly associated with an increased risk of developing prostate cancer and reduced circulating MSMB levels, establishing its importance in oncology.