人孕酮受体抗体对
01AB03418
Progesterone receptor (PGR), also known as NR3C3, is a member of the nuclear receptor superfamily and functions as a transcription factor activated by the steroid hormone progesterone. It exists in two isoforms, PRA and PRB, which differ in their regulatory roles; PRB primarily promotes progesterone's effects, while PRA can antagonize them. Upon progesterone binding, PGR undergoes conformational changes that enable it to dimerize and translocate to the nucleus, where it binds to specific DNA sequences to regulate gene expression critical for reproductive processes, including mammary gland development and menstrual cycle regulation. Dysregulation of PGR is implicated in various diseases, particularly hormone-dependent cancers such as breast cancer. Overexpression of PGR has been associated with increased cell proliferation and tumor progression. Additionally, polymorphisms in the PGR gene can influence individual responses to hormone therapy and risk for developing certain cancers.
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技术参数
- 靶点基因名
- PGR
- 基因别名
- NR3C3
- 蛋白别名
- progesterone receptor; Progesterone Receptor
- UniProt
- P06401
- 物种
- Human
产品详情
- 靶点名称
- Progesterone Receptor
- 蛋白名称
- progesterone receptor
- 蛋白别名
- Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3
- 靶点基因名
- PGR
- 基因别名
- NR3C3
- UniProt
- P06401
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Progesterone receptor (PGR), also known as NR3C3, is a member of the nuclear receptor superfamily and functions as a transcription factor activated by the steroid hormone progesterone. It exists in two isoforms, PRA and PRB, which differ in their regulatory roles; PRB primarily promotes progesterone's effects, while PRA can antagonize them. Upon progesterone binding, PGR undergoes conformational changes that enable it to dimerize and translocate to the nucleus, where it binds to specific DNA sequences to regulate gene expression critical for reproductive processes, including mammary gland development and menstrual cycle regulation. Dysregulation of PGR is implicated in various diseases, particularly hormone-dependent cancers such as breast cancer. Overexpression of PGR has been associated with increased cell proliferation and tumor progression. Additionally, polymorphisms in the PGR gene can influence individual responses to hormone therapy and risk for developing certain cancers.