人 PRKCQ 抗体对
01AB03523
Protein kinase C theta (PRKCQ) is a serine/threonine kinase that plays a crucial role in T cell activation and immune responses. It is primarily expressed in hematopoietic cells, particularly T lymphocytes, where it is involved in the signaling pathways activated by the T cell receptor (TCR) and CD28 co-stimulation. PRKCQ is essential for the activation of transcription factors such as NF-κB and AP-1, which regulate gene expression related to T cell proliferation and survival. Dysregulation of PRKCQ has been linked to several diseases, including autoimmune disorders and certain cancers. In particular, its overexpression in triple-negative breast cancer (TNBC) has been associated with increased tumor growth, resistance to anoikis, and enhanced epithelial-mesenchymal transition (EMT), contributing to metastasis. Additionally, PRKCQ's role in promoting Th17 cell differentiation links it to inflammatory conditions.
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技术参数
- 靶点基因名
- PRKCQ
- 基因别名
- PRKCT
- 蛋白别名
- protein kinase C theta; PRKCQ
- UniProt
- Q04759
- 物种
- Human
产品详情
- 靶点名称
- PRKCQ
- 蛋白名称
- protein kinase C theta
- 蛋白别名
- Protein kinase C theta type; nPKC-theta
- 靶点基因名
- PRKCQ
- 基因别名
- PRKCT
- UniProt
- Q04759
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein kinase C theta (PRKCQ) is a serine/threonine kinase that plays a crucial role in T cell activation and immune responses. It is primarily expressed in hematopoietic cells, particularly T lymphocytes, where it is involved in the signaling pathways activated by the T cell receptor (TCR) and CD28 co-stimulation. PRKCQ is essential for the activation of transcription factors such as NF-κB and AP-1, which regulate gene expression related to T cell proliferation and survival. Dysregulation of PRKCQ has been linked to several diseases, including autoimmune disorders and certain cancers. In particular, its overexpression in triple-negative breast cancer (TNBC) has been associated with increased tumor growth, resistance to anoikis, and enhanced epithelial-mesenchymal transition (EMT), contributing to metastasis. Additionally, PRKCQ's role in promoting Th17 cell differentiation links it to inflammatory conditions.