人 PRELP 抗体对
01AB01813
Proline and arginine rich end leucine rich repeat protein (PRELP) is a secreted extracellular matrix protein belonging to the small leucine-rich proteoglycan (SLRP) family. It is primarily found in connective tissues and basement membranes, where it acts as a bridge between the basement membrane and the underlying matrix. PRELP utilizes its proline- and arginine-rich N-terminal domain to bind heparin and heparan sulfate, while its C-terminal leucine-rich repeat region interacts with type I and II collagens and perlecan. It also modulates the complement system by binding C3 and C9 to inhibit the formation of the membrane attack complex. This protective role is particularly relevant in inflammatory conditions such as rheumatoid arthritis, where PRELP helps regulate local immune responses and maintain vascular integrity.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- PRELP
- 基因别名
- SLRR2A
- 蛋白别名
- proline and arginine rich end leucine rich repeat protein; PRELP
- UniProt
- P51888
- 物种
- Human
产品详情
- 靶点名称
- PRELP
- 蛋白名称
- proline and arginine rich end leucine rich repeat protein
- 蛋白别名
- Prolargin; Proline-arginine-rich end leucine-rich repeat protein
- 靶点基因名
- PRELP
- 基因别名
- SLRR2A
- UniProt
- P51888
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proline and arginine rich end leucine rich repeat protein (PRELP) is a secreted extracellular matrix protein belonging to the small leucine-rich proteoglycan (SLRP) family. It is primarily found in connective tissues and basement membranes, where it acts as a bridge between the basement membrane and the underlying matrix. PRELP utilizes its proline- and arginine-rich N-terminal domain to bind heparin and heparan sulfate, while its C-terminal leucine-rich repeat region interacts with type I and II collagens and perlecan. It also modulates the complement system by binding C3 and C9 to inhibit the formation of the membrane attack complex. This protective role is particularly relevant in inflammatory conditions such as rheumatoid arthritis, where PRELP helps regulate local immune responses and maintain vascular integrity.