人 PREB 抗体对
01AB00353
Prolactin regulatory element binding (PREB) protein is a transcription factor that plays a crucial role in regulating prolactin (PRL) gene expression. It specifically binds to a Pit1-binding element of the PRL promoter and is involved in the homeostatic regulation of PRL promoter activity. PREB contains two PQ-rich potential transactivation domains but lacks a discernible DNA-binding motif, exhibiting sequence-specific binding to the PRL promoter site 1P. Beyond its role in pituitary function, PREB has been implicated in the regulation of hepatic glucose metabolism, acting as a negative regulator of liver gluconeogenic genes by directly binding to their promoters at a prolactin core-binding element (PCBE). This suggests that PREB may play a broader role in metabolic regulation, potentially contributing to the pathogenesis of metabolic syndrome, obesity, and type-2 diabetes mellitus.
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技术参数
- 靶点基因名
- PREB
- 基因别名
- SEC12
- 蛋白别名
- prolactin regulatory element binding; PREB
- UniProt
- Q9HCU5
- 物种
- Human
产品详情
- 靶点名称
- PREB
- 蛋白名称
- prolactin regulatory element binding
- 蛋白别名
- Prolactin regulatory element-binding protein; Mammalian guanine nucleotide exchange factor mSec12
- 靶点基因名
- PREB
- 基因别名
- SEC12
- UniProt
- Q9HCU5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Prolactin regulatory element binding (PREB) protein is a transcription factor that plays a crucial role in regulating prolactin (PRL) gene expression. It specifically binds to a Pit1-binding element of the PRL promoter and is involved in the homeostatic regulation of PRL promoter activity. PREB contains two PQ-rich potential transactivation domains but lacks a discernible DNA-binding motif, exhibiting sequence-specific binding to the PRL promoter site 1P. Beyond its role in pituitary function, PREB has been implicated in the regulation of hepatic glucose metabolism, acting as a negative regulator of liver gluconeogenic genes by directly binding to their promoters at a prolactin core-binding element (PCBE). This suggests that PREB may play a broader role in metabolic regulation, potentially contributing to the pathogenesis of metabolic syndrome, obesity, and type-2 diabetes mellitus.