人 PRAS40 抗体对
01AB02880
Proline-rich AKT1 substrate 1 (AKT1S1), also known as PRAS40, is a critical regulatory protein that interacts with the AKT signaling pathway, which is essential for cell growth, survival, and metabolism. AKT1S1 functions as a negative regulator of AKT by binding to its phosphorylated form, thereby inhibiting its activity. This protein is characterized by its proline-rich domain, which facilitates interactions with various signaling molecules. Dysregulation of AKT1S1 has been implicated in several diseases, particularly cancer and metabolic disorders. For instance, decreased expression of AKT1S1 has been associated with increased tumorigenesis and poor prognosis in cancers such as breast and prostate cancer, where enhanced AKT activity promotes cell proliferation and survival. Additionally, alterations in AKT1S1 expression have been linked to insulin resistance and type 2 diabetes, highlighting its role in metabolic regulation.
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技术参数
- 靶点基因名
- AKT1S1
- 基因别名
- PRAS40
- 蛋白别名
- AKT1 substrate 1; PRAS40
- UniProt
- Q96B36
- 物种
- Human
产品详情
- 靶点名称
- PRAS40
- 蛋白名称
- AKT1 substrate 1
- 蛋白别名
- Proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate
- 靶点基因名
- AKT1S1
- 基因别名
- PRAS40
- UniProt
- Q96B36
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proline-rich AKT1 substrate 1 (AKT1S1), also known as PRAS40, is a critical regulatory protein that interacts with the AKT signaling pathway, which is essential for cell growth, survival, and metabolism. AKT1S1 functions as a negative regulator of AKT by binding to its phosphorylated form, thereby inhibiting its activity. This protein is characterized by its proline-rich domain, which facilitates interactions with various signaling molecules. Dysregulation of AKT1S1 has been implicated in several diseases, particularly cancer and metabolic disorders. For instance, decreased expression of AKT1S1 has been associated with increased tumorigenesis and poor prognosis in cancers such as breast and prostate cancer, where enhanced AKT activity promotes cell proliferation and survival. Additionally, alterations in AKT1S1 expression have been linked to insulin resistance and type 2 diabetes, highlighting its role in metabolic regulation.