人 PR3 抗体对
01AB00356
Proteinase 3 (PRTN3) is a serine protease enzyme primarily expressed in neutrophil granulocytes. It plays a role in the proteolytic generation of antimicrobial peptides and is the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA class, commonly found in granulomatosis with polyangiitis (GPA). PRTN3 is externalized during apoptosis and interacts with phospholipid scramblase 1 (PLSCR1), which is involved in the bidirectional movement of plasma membrane phospholipids. This externalization can interfere with macrophage clearance of apoptotic neutrophils, contributing to the pathogenesis of ANCA-associated vasculitis and other inflammatory diseases. High levels of membrane PR3 expression are associated with chronic inflammatory diseases such as vasculitides and rheumatoid arthritis.
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技术参数
- 靶点基因名
- PRTN3
- 基因别名
- MBN
- 蛋白别名
- proteinase 3; PR3
- UniProt
- P24158
- 物种
- Human
产品详情
- 靶点名称
- PR3
- 蛋白名称
- proteinase 3
- 蛋白别名
- Myeloblastin; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
- 靶点基因名
- PRTN3
- 基因别名
- MBN
- UniProt
- P24158
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proteinase 3 (PRTN3) is a serine protease enzyme primarily expressed in neutrophil granulocytes. It plays a role in the proteolytic generation of antimicrobial peptides and is the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA class, commonly found in granulomatosis with polyangiitis (GPA). PRTN3 is externalized during apoptosis and interacts with phospholipid scramblase 1 (PLSCR1), which is involved in the bidirectional movement of plasma membrane phospholipids. This externalization can interfere with macrophage clearance of apoptotic neutrophils, contributing to the pathogenesis of ANCA-associated vasculitis and other inflammatory diseases. High levels of membrane PR3 expression are associated with chronic inflammatory diseases such as vasculitides and rheumatoid arthritis.