抗人 PPP1R7 抗体对
01AB03001
Protein phosphatase 1 regulatory subunit 7 (PPP1R7), also known as SDS22, is a conserved regulatory subunit of serine/threonine protein phosphatase 1 (PP1). It binds PP1 catalytic subunits with high affinity, modulating their activity, subcellular localization, and substrate specificity. PPP1R7 is critical for mitotic spindle function and chromosome segregation. In cardiac tissue, it acts as a major regulator of the PP1 interactome; its deficiency leads to impaired contractile function and altered calcium handling. Genetically, the PPP1R7 locus is located in a region associated with 2q37 deletion syndrome and gnathodiaphyseal dysplasia, linking it to developmental anomalies.
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技术参数
- 靶点基因名
- PPP1R7
- 基因别名
- SDS22
- 蛋白别名
- protein phosphatase 1 regulatory subunit 7; PPP1R7
- UniProt
- Q15435
- 物种
- Human
产品详情
- 靶点名称
- PPP1R7
- 蛋白名称
- protein phosphatase 1 regulatory subunit 7
- 蛋白别名
- Protein phosphatase 1 regulatory subunit 7; Protein phosphatase 1 regulatory subunit 22
- 靶点基因名
- PPP1R7
- 基因别名
- SDS22
- UniProt
- Q15435
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein phosphatase 1 regulatory subunit 7 (PPP1R7), also known as SDS22, is a conserved regulatory subunit of serine/threonine protein phosphatase 1 (PP1). It binds PP1 catalytic subunits with high affinity, modulating their activity, subcellular localization, and substrate specificity. PPP1R7 is critical for mitotic spindle function and chromosome segregation. In cardiac tissue, it acts as a major regulator of the PP1 interactome; its deficiency leads to impaired contractile function and altered calcium handling. Genetically, the PPP1R7 locus is located in a region associated with 2q37 deletion syndrome and gnathodiaphyseal dysplasia, linking it to developmental anomalies.