人 PPP1R2 抗体对
01AB04138
Protein phosphatase 1 regulatory inhibitor subunit 2 (PPP1R2), plays a crucial role in regulating protein phosphatase 1 (PP1), a key enzyme involved in various cellular processes, including glycogen metabolism and cell division. This protein, which is expressed in multiple tissues, functions primarily as an inhibitor of PP1 by stabilizing specific holoenzyme complexes, thus modulating the dephosphorylation of substrates. Its regulatory activity is complex; while it can inhibit PP1's function by occluding the active site, it also promotes the stability of certain PP1 complexes, enhancing their activity under specific conditions. Dysregulation of PPP1R2 has been implicated in several diseases, including cancer, where it may contribute to abnormal cell division and proliferation.
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技术参数
- 靶点基因名
- PPP1R2
- 基因别名
- IPP2
- 蛋白别名
- protein phosphatase 1 regulatory inhibitor subunit 2; PPP1R2
- UniProt
- P41236
- 物种
- Human
产品详情
- 靶点名称
- PPP1R2
- 蛋白名称
- protein phosphatase 1 regulatory inhibitor subunit 2
- 蛋白别名
- Protein phosphatase inhibitor 2; IPP-2
- 靶点基因名
- PPP1R2
- 基因别名
- IPP2
- UniProt
- P41236
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein phosphatase 1 regulatory inhibitor subunit 2 (PPP1R2), plays a crucial role in regulating protein phosphatase 1 (PP1), a key enzyme involved in various cellular processes, including glycogen metabolism and cell division. This protein, which is expressed in multiple tissues, functions primarily as an inhibitor of PP1 by stabilizing specific holoenzyme complexes, thus modulating the dephosphorylation of substrates. Its regulatory activity is complex; while it can inhibit PP1's function by occluding the active site, it also promotes the stability of certain PP1 complexes, enhancing their activity under specific conditions. Dysregulation of PPP1R2 has been implicated in several diseases, including cancer, where it may contribute to abnormal cell division and proliferation.