人 PPP1R14A 抗体对
01AB00560
Protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), also known as CPI-17, is a protein that plays a crucial role in regulating smooth muscle contraction and has been implicated in various cancers. It acts as a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase, with over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation state of PPP1CA substrate and smooth muscle contraction. In cancer, PPP1R14A has been associated with tumorigenesis and progression, particularly in sporadic vestibular glioma, human melanoma, and schwannoma. High expression of PPP1R14A in most cases is linked to poor overall survival, disease-specific survival, and progress-free interval across patients with various malignant tumors, including adrenocortical carcinoma and bladder urothelial carcinoma.
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技术参数
- 靶点基因名
- PPP1R14A
- 基因别名
- CPI17; PPP1INL
- 蛋白别名
- protein phosphatase 1 regulatory inhibitor subunit 14A; PPP1R14A
- UniProt
- Q96A00
- 物种
- Human
产品详情
- 靶点名称
- PPP1R14A
- 蛋白名称
- protein phosphatase 1 regulatory inhibitor subunit 14A
- 蛋白别名
- Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17
- 靶点基因名
- PPP1R14A
- 基因别名
- CPI17; PPP1INL
- UniProt
- Q96A00
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), also known as CPI-17, is a protein that plays a crucial role in regulating smooth muscle contraction and has been implicated in various cancers. It acts as a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase, with over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation state of PPP1CA substrate and smooth muscle contraction. In cancer, PPP1R14A has been associated with tumorigenesis and progression, particularly in sporadic vestibular glioma, human melanoma, and schwannoma. High expression of PPP1R14A in most cases is linked to poor overall survival, disease-specific survival, and progress-free interval across patients with various malignant tumors, including adrenocortical carcinoma and bladder urothelial carcinoma.