人 PPM1B 抗体对
01AB00351
Protein phosphatase, Mg2+/Mn2+ dependent 1B (PPM1B) is a serine/threonine phosphatase with broad specificity. It dephosphorylates various proteins, including CDK2, CDK6, PRKAA1, PRKAA2, and TBK1, thereby regulating cellular processes such as cell cycle progression and antiviral signaling. PPM1B also plays a crucial role in terminating TNF-alpha-mediated NF-kappa-B activation by dephosphorylating and inactivating IKBKB/IKKB. Additionally, it has been shown to inhibit DYRK1A kinase through dephosphorylation, which reduces tau oligomerization and aggregation, suggesting a potential role in neurodegenerative diseases like Alzheimer's disease. PPM1B is associated with various diseases, including Alzheimer's disease and Down syndrome, highlighting its importance in maintaining cellular homeostasis.
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技术参数
- 靶点基因名
- PPM1B
- 基因别名
- PP2CB
- 蛋白别名
- protein phosphatase, Mg2+/Mn2+ dependent 1B; PPM1B
- UniProt
- O75688
- 物种
- Human
产品详情
- 靶点名称
- PPM1B
- 蛋白名称
- protein phosphatase, Mg2+/Mn2+ dependent 1B
- 蛋白别名
- Protein phosphatase 1B; Protein phosphatase 2C isoform beta; PP2C-beta
- 靶点基因名
- PPM1B
- 基因别名
- PP2CB
- UniProt
- O75688
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein phosphatase, Mg2+/Mn2+ dependent 1B (PPM1B) is a serine/threonine phosphatase with broad specificity. It dephosphorylates various proteins, including CDK2, CDK6, PRKAA1, PRKAA2, and TBK1, thereby regulating cellular processes such as cell cycle progression and antiviral signaling. PPM1B also plays a crucial role in terminating TNF-alpha-mediated NF-kappa-B activation by dephosphorylating and inactivating IKBKB/IKKB. Additionally, it has been shown to inhibit DYRK1A kinase through dephosphorylation, which reduces tau oligomerization and aggregation, suggesting a potential role in neurodegenerative diseases like Alzheimer's disease. PPM1B is associated with various diseases, including Alzheimer's disease and Down syndrome, highlighting its importance in maintaining cellular homeostasis.