人 PON1 抗体对
01AB04135
Serum paraoxonase/arylesterase 1 (PON1) is a calcium-dependent enzyme that is primarily associated with high-density lipoproteins (HDL) and plays a significant role in lipid metabolism and antioxidant defense. It is involved in the hydrolysis of various substrates, including organophosphates and oxidized lipids, contributing to its atheroprotective properties by preventing the accumulation of oxidized low-density lipoprotein (LDL) cholesterol. Variations in the PON1 gene, particularly polymorphisms such as Q192R and L55M, can significantly affect enzyme activity and serum levels, influencing individual susceptibility to cardiovascular diseases. Low PON1 activity has been linked to an increased risk of atherosclerosis, diabetes, and neurodegenerative diseases.
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技术参数
- 靶点基因名
- PON1
- 基因别名
- PON
- 蛋白别名
- paraoxonase 1; PON1
- UniProt
- P27169
- 物种
- Human
产品详情
- 靶点名称
- PON1
- 蛋白名称
- paraoxonase 1
- 蛋白别名
- Serum paraoxonase/arylesterase 1; PON 1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1
- 靶点基因名
- PON1
- 基因别名
- PON
- UniProt
- P27169
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Serum paraoxonase/arylesterase 1 (PON1) is a calcium-dependent enzyme that is primarily associated with high-density lipoproteins (HDL) and plays a significant role in lipid metabolism and antioxidant defense. It is involved in the hydrolysis of various substrates, including organophosphates and oxidized lipids, contributing to its atheroprotective properties by preventing the accumulation of oxidized low-density lipoprotein (LDL) cholesterol. Variations in the PON1 gene, particularly polymorphisms such as Q192R and L55M, can significantly affect enzyme activity and serum levels, influencing individual susceptibility to cardiovascular diseases. Low PON1 activity has been linked to an increased risk of atherosclerosis, diabetes, and neurodegenerative diseases.