抗人 PLXNA4 抗体对
01AB02009
Plexin A4 (PLXNA4) is a large type I transmembrane glycoprotein receptor that functions as a coreceptor for class 3 and class 6 semaphorins, such as SEMA3A and SEMA6A. Through its cytoplasmic region, it regulates Rho-family GTPases and cytoskeletal remodeling to mediate critical processes including axon guidance, growth cone collapse, and dendritic branching. PLXNA4 is highly expressed in the central nervous system and plays a significant role in neural development and vascular remodeling. Clinically, PLXNA4 is strongly implicated in Alzheimer’s disease, where risk variants and increased expression levels correlate with enhanced tau phosphorylation and the severity of tau pathology. It is also associated with glioblastoma progression and tumor angiogenesis, reflecting its broader role in signaling and tissue architecture.
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技术参数
- 靶点基因名
- PLXNA4
- 基因别名
- KIAA1550; PLXNA4A; PLXNA4B
- 蛋白别名
- plexin A4; PLXNA4
- UniProt
- Q9HCM2
- 物种
- Human
产品详情
- 靶点名称
- PLXNA4
- 蛋白名称
- plexin A4
- 蛋白别名
- Plexin-A4
- 靶点基因名
- PLXNA4
- 基因别名
- KIAA1550; PLXNA4A; PLXNA4B
- UniProt
- Q9HCM2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Plexin A4 (PLXNA4) is a large type I transmembrane glycoprotein receptor that functions as a coreceptor for class 3 and class 6 semaphorins, such as SEMA3A and SEMA6A. Through its cytoplasmic region, it regulates Rho-family GTPases and cytoskeletal remodeling to mediate critical processes including axon guidance, growth cone collapse, and dendritic branching. PLXNA4 is highly expressed in the central nervous system and plays a significant role in neural development and vascular remodeling. Clinically, PLXNA4 is strongly implicated in Alzheimer’s disease, where risk variants and increased expression levels correlate with enhanced tau phosphorylation and the severity of tau pathology. It is also associated with glioblastoma progression and tumor angiogenesis, reflecting its broader role in signaling and tissue architecture.