人 PLXDC1 抗体对
01AB00344
Plexin domain containing 1 (PLXDC1) is a single-pass type I membrane protein belonging to the plexin family. It plays a critical role in endothelial cell capillary morphogenesis and is predominantly localized at the tight junctions of vascular endothelial cells. PLXDC1 is expressed in fibrovascular membranes with increased expression in individuals with proliferative diabetic retinopathy and can be detected in endothelial cells from various cancers, including colorectal, lung, liver, pancreas, breast, and brain cancers. PLXDC1 interacts with NID1 and may also interact with CTTN, contributing to the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs). Additionally, PLXDC1 has been identified as a receptor for PEDF (Pigment Epithelium-Derived Factor), a protein involved in cell survival and death pathways.
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技术参数
- 靶点基因名
- PLXDC1
- 基因别名
- TEM3; TEM7
- 蛋白别名
- plexin domain containing 1; PLXDC1
- UniProt
- Q8IUK5
- 物种
- Human
产品详情
- 靶点名称
- PLXDC1
- 蛋白名称
- plexin domain containing 1
- 蛋白别名
- Plexin domain-containing protein 1; Tumor endothelial marker 3; Tumor endothelial marker 7
- 靶点基因名
- PLXDC1
- 基因别名
- TEM3; TEM7
- UniProt
- Q8IUK5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Plexin domain containing 1 (PLXDC1) is a single-pass type I membrane protein belonging to the plexin family. It plays a critical role in endothelial cell capillary morphogenesis and is predominantly localized at the tight junctions of vascular endothelial cells. PLXDC1 is expressed in fibrovascular membranes with increased expression in individuals with proliferative diabetic retinopathy and can be detected in endothelial cells from various cancers, including colorectal, lung, liver, pancreas, breast, and brain cancers. PLXDC1 interacts with NID1 and may also interact with CTTN, contributing to the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs). Additionally, PLXDC1 has been identified as a receptor for PEDF (Pigment Epithelium-Derived Factor), a protein involved in cell survival and death pathways.