人 PLTP 抗体对
01AB03413
Phospholipid transfer protein (PLTP) is a plasma protein that plays a critical role in lipid metabolism by mediating the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins, such as low-density lipoproteins (LDL) and very-low-density lipoproteins (VLDL), to high-density lipoproteins (HDL). Structurally characterized by a distinctive banana-shaped fold similar to cholesteryl ester transfer protein (CETP), PLTP functions by penetrating lipoprotein surfaces to form ternary complexes that facilitate lipid remodeling and regulate HDL particle size. The protein interacts with apolipoprotein A1 and A2 to participate in reverse cholesterol transport pathways. Beyond its physiological role in maintaining lipid homeostasis, PLTP dysfunction is well-established in the pathogenesis of dyslipidemia and cardiovascular disease. Consequently, it serves as a significant therapeutic target for treating lipoprotein abnormalities and reducing the risk of atherosclerotic complications.
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技术参数
- 靶点基因名
- PLTP
- 蛋白别名
- phospholipid transfer protein; PLTP
- UniProt
- P55058
- 物种
- Human
产品详情
- 靶点名称
- PLTP
- 蛋白名称
- phospholipid transfer protein
- 蛋白别名
- Phospholipid transfer protein; Lipid transfer protein II
- 靶点基因名
- PLTP
- UniProt
- P55058
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phospholipid transfer protein (PLTP) is a plasma protein that plays a critical role in lipid metabolism by mediating the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins, such as low-density lipoproteins (LDL) and very-low-density lipoproteins (VLDL), to high-density lipoproteins (HDL). Structurally characterized by a distinctive banana-shaped fold similar to cholesteryl ester transfer protein (CETP), PLTP functions by penetrating lipoprotein surfaces to form ternary complexes that facilitate lipid remodeling and regulate HDL particle size. The protein interacts with apolipoprotein A1 and A2 to participate in reverse cholesterol transport pathways. Beyond its physiological role in maintaining lipid homeostasis, PLTP dysfunction is well-established in the pathogenesis of dyslipidemia and cardiovascular disease. Consequently, it serves as a significant therapeutic target for treating lipoprotein abnormalities and reducing the risk of atherosclerotic complications.