人 PLEKHO2 抗体对
01AB01554
Pleckstrin homology domain containing O2 (PLEKHO2) is a protein characterized by the presence of a pleckstrin homology (PH) domain, which typically mediates interactions with phosphoinositides and proteins, facilitating membrane localization and signal transduction. PLEKHO2 is involved in cellular processes such as cytoskeletal organization, cell migration, and innate immune responses, with functional associations in pathways like the MAPK signaling cascade. It is expressed in various tissues and participates in protein-protein interactions critical for cell signaling and apoptosis regulation. Disease-wise, PLEKHO2 has been implicated in cancer progression, notably colorectal cancer, where the miR-106b/NR2F2-AS1/PLEKHO2 axis regulates tumor cell migration and invasion through the MAPK pathway. Its dysregulation may contribute to tumor metastasis.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- PLEKHO2
- 基因别名
- PLEKHQ1
- 蛋白别名
- pleckstrin homology domain containing O2; PLEKHO2
- UniProt
- Q8TD55
- 物种
- Human
产品详情
- 靶点名称
- PLEKHO2
- 蛋白名称
- pleckstrin homology domain containing O2
- 蛋白别名
- Pleckstrin homology domain-containing family O member 2; PH domain-containing family O member 2; Pleckstrin homology domain-containing family Q member 1; PH domain-containing family Q member 1
- 靶点基因名
- PLEKHO2
- 基因别名
- PLEKHQ1
- UniProt
- Q8TD55
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Pleckstrin homology domain containing O2 (PLEKHO2) is a protein characterized by the presence of a pleckstrin homology (PH) domain, which typically mediates interactions with phosphoinositides and proteins, facilitating membrane localization and signal transduction. PLEKHO2 is involved in cellular processes such as cytoskeletal organization, cell migration, and innate immune responses, with functional associations in pathways like the MAPK signaling cascade. It is expressed in various tissues and participates in protein-protein interactions critical for cell signaling and apoptosis regulation. Disease-wise, PLEKHO2 has been implicated in cancer progression, notably colorectal cancer, where the miR-106b/NR2F2-AS1/PLEKHO2 axis regulates tumor cell migration and invasion through the MAPK pathway. Its dysregulation may contribute to tumor metastasis.