抗人 PLEKHG1 抗体对
01AB03381
Pleckstrin homology and RhoGEF domain containing G1 (PLEKHG1) is a guanine nucleotide exchange factor (GEF) that specifically activates the small GTPases RAC1 and CDC42. By facilitating the exchange of GDP for GTP, PLEKHG1 regulates cell morphology and actin cytoskeletal reorganization. The protein is activated through interaction with the Src family kinase FYN, which phosphorylates PLEKHG1 at multiple tyrosine residues, including Tyr-720 and Tyr-801, thereby enhancing its GEF activity and promoting Rho-dependent signaling. PLEKHG1 is primarily localized in the nucleoplasm and shares significant sequence identity with its paralog PLEKHG2. Clinically, genetic variations in PLEKHG1 are strongly associated with white matter hyperintensities and the small vessel subtype of ischemic stroke. Furthermore, its involvement in signal transduction pathways has linked it to the progression of prostate cancer and panic disorder.
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技术参数
- 靶点基因名
- PLEKHG1
- 基因别名
- KIAA1209
- 蛋白别名
- pleckstrin homology and RhoGEF domain containing G1; PLEKHG1
- UniProt
- Q9ULL1
- 物种
- Human
产品详情
- 靶点名称
- PLEKHG1
- 蛋白名称
- pleckstrin homology and RhoGEF domain containing G1
- 蛋白别名
- Pleckstrin homology domain-containing family G member 1
- 靶点基因名
- PLEKHG1
- 基因别名
- KIAA1209
- UniProt
- Q9ULL1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Pleckstrin homology and RhoGEF domain containing G1 (PLEKHG1) is a guanine nucleotide exchange factor (GEF) that specifically activates the small GTPases RAC1 and CDC42. By facilitating the exchange of GDP for GTP, PLEKHG1 regulates cell morphology and actin cytoskeletal reorganization. The protein is activated through interaction with the Src family kinase FYN, which phosphorylates PLEKHG1 at multiple tyrosine residues, including Tyr-720 and Tyr-801, thereby enhancing its GEF activity and promoting Rho-dependent signaling. PLEKHG1 is primarily localized in the nucleoplasm and shares significant sequence identity with its paralog PLEKHG2. Clinically, genetic variations in PLEKHG1 are strongly associated with white matter hyperintensities and the small vessel subtype of ischemic stroke. Furthermore, its involvement in signal transduction pathways has linked it to the progression of prostate cancer and panic disorder.