人 PLCH2 抗体对
01AB01804
Phospholipase C eta 2 (PLCH2) is a phosphoinositide-specific phospholipase C isozyme that plays a vital role in intracellular signaling. It catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate the second messengers inositol 1,4,5-trisphosphate and diacylglycerol, which subsequently trigger calcium mobilization and protein kinase C activation. Structurally, PLCH2 contains a conserved catalytic core comprising an N-terminal pleckstrin homology domain, EF-hand calcium-binding motifs, a split X/Y catalytic domain, and a C2 domain. It is distinguished by its high sensitivity to calcium ions, exceeding that of other PLC family members, which suggests a specialized role in amplifying calcium-dependent signaling in neuronal and immune contexts.
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技术参数
- 靶点基因名
- PLCH2
- 基因别名
- KIAA0450; PLCL4
- 蛋白别名
- phospholipase C eta 2; PLCH2
- UniProt
- O75038
- 物种
- Human
产品详情
- 靶点名称
- PLCH2
- 蛋白名称
- phospholipase C eta 2
- 蛋白别名
- 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase eta-2; Phosphoinositide phospholipase C-eta-2; Phosphoinositide phospholipase C-like 4; PLC-L4; Phospholipase C-like protein 4; Phospholipase C-eta-2; PLC-eta2
- 靶点基因名
- PLCH2
- 基因别名
- KIAA0450; PLCL4
- UniProt
- O75038
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phospholipase C eta 2 (PLCH2) is a phosphoinositide-specific phospholipase C isozyme that plays a vital role in intracellular signaling. It catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate the second messengers inositol 1,4,5-trisphosphate and diacylglycerol, which subsequently trigger calcium mobilization and protein kinase C activation. Structurally, PLCH2 contains a conserved catalytic core comprising an N-terminal pleckstrin homology domain, EF-hand calcium-binding motifs, a split X/Y catalytic domain, and a C2 domain. It is distinguished by its high sensitivity to calcium ions, exceeding that of other PLC family members, which suggests a specialized role in amplifying calcium-dependent signaling in neuronal and immune contexts.