人 PLA2G7 抗体对
01AB01794
Phospholipase A2 group VII (PLA2G7) is a secreted, calcium-independent phospholipase A2 that circulates in the blood primarily bound to LDL and HDL. Also known as lipoprotein-associated phospholipase A2 (Lp-PLA2), it hydrolyzes the sn-2 ester bond of phospholipids, specifically targeting short-chain or oxidized fatty acyl groups. This activity inactivates platelet-activating factor (PAF) and degrades pro-inflammatory oxidized phospholipids, thereby modulating vascular inflammation. Clinically, elevated levels of circulating PLA2G7 mass or activity are strongly associated with atherosclerosis, coronary artery disease, and ischemic stroke. Consequently, it is widely utilized as a biomarker for vascular inflammation and plaque instability and is considered a potential therapeutic target for cardiovascular and cerebrovascular disorders.
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技术参数
- 靶点基因名
- PLA2G7
- 基因别名
- PAFAH
- 蛋白别名
- phospholipase A2 group VII; PLA2G7
- UniProt
- Q13093
- 物种
- Human
产品详情
- 靶点名称
- PLA2G7
- 蛋白名称
- phospholipase A2 group VII
- 蛋白别名
- Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA(2); PAF 2-acylhydrolase
- 靶点基因名
- PLA2G7
- 基因别名
- PAFAH
- UniProt
- Q13093
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phospholipase A2 group VII (PLA2G7) is a secreted, calcium-independent phospholipase A2 that circulates in the blood primarily bound to LDL and HDL. Also known as lipoprotein-associated phospholipase A2 (Lp-PLA2), it hydrolyzes the sn-2 ester bond of phospholipids, specifically targeting short-chain or oxidized fatty acyl groups. This activity inactivates platelet-activating factor (PAF) and degrades pro-inflammatory oxidized phospholipids, thereby modulating vascular inflammation. Clinically, elevated levels of circulating PLA2G7 mass or activity are strongly associated with atherosclerosis, coronary artery disease, and ischemic stroke. Consequently, it is widely utilized as a biomarker for vascular inflammation and plaque instability and is considered a potential therapeutic target for cardiovascular and cerebrovascular disorders.