抗人 PITPNC1 抗体对
01AB02005
Phosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) is a cytoplasmic protein encoded by the PITPNC1 gene, belonging to the phosphatidylinositol transfer protein family and primarily involved in lipid metabolism and cell signaling by facilitating the transfer of phosphatidylinositol and phosphatidic acid between membrane compartments. PITPNC1 exists in multiple isoforms due to alternative splicing, with distinct C-terminal extensions influencing its lipid transfer activity; compared to Class I PITPs, PITPNC1 exhibits lower phosphatidylinositol transfer activity and uniquely binds phosphatidic acid, especially upon phospholipase D activation. Functionally, PITPNC1 activates pathways related to cell adhesion and immune receptor signaling while inhibiting RNA metabolism pathways. Clinically, reduced PITPNC1 expression has been observed in prostate cancer tissues, correlating with earlier biochemical recurrence, decreased overall survival, and higher TP53 mutation frequency; lower PITPNC1 levels also predict poorer immunotherapy outcomes and identify patients who may benefit from targeted therapies such as Rucaparib.
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技术参数
- 靶点基因名
- PITPNC1
- 蛋白别名
- phosphatidylinositol transfer protein cytoplasmic 1; PITPNC1
- UniProt
- Q9UKF7
- 物种
- Human
产品详情
- 靶点名称
- PITPNC1
- 蛋白名称
- phosphatidylinositol transfer protein cytoplasmic 1
- 蛋白别名
- Cytoplasmic phosphatidylinositol transfer protein 1; Mammalian rdgB homolog beta; M-rdgB beta; MrdgBbeta; Retinal degeneration B homolog beta; RdgBbeta
- 靶点基因名
- PITPNC1
- UniProt
- Q9UKF7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) is a cytoplasmic protein encoded by the PITPNC1 gene, belonging to the phosphatidylinositol transfer protein family and primarily involved in lipid metabolism and cell signaling by facilitating the transfer of phosphatidylinositol and phosphatidic acid between membrane compartments. PITPNC1 exists in multiple isoforms due to alternative splicing, with distinct C-terminal extensions influencing its lipid transfer activity; compared to Class I PITPs, PITPNC1 exhibits lower phosphatidylinositol transfer activity and uniquely binds phosphatidic acid, especially upon phospholipase D activation. Functionally, PITPNC1 activates pathways related to cell adhesion and immune receptor signaling while inhibiting RNA metabolism pathways. Clinically, reduced PITPNC1 expression has been observed in prostate cancer tissues, correlating with earlier biochemical recurrence, decreased overall survival, and higher TP53 mutation frequency; lower PITPNC1 levels also predict poorer immunotherapy outcomes and identify patients who may benefit from targeted therapies such as Rucaparib.