人 PITPNB 抗体对
01AB02521
Phosphatidylinositol transfer protein beta (PITPNB) is a cytosolic lipid-transfer protein that facilitates the movement of phosphatidylinositol (PI) and phosphatidylcholine (PC) between cellular membranes. It utilizes a hydrophobic cavity to shield individual lipids during transport, supporting phosphoinositide synthesis by delivering PI to specific PI kinases and phospholipases. PITPNB is a member of the SRPBCC superfamily and contains an N-terminal lipid-binding core that mediates membrane association and lipid exchange. By maintaining local phosphoinositide pools, it regulates phosphoinositide-dependent signaling, vesicular trafficking, and regulated exocytosis. While it shares functional similarities with PITP-alpha, PITPNB maintains distinct roles in coordinating membrane dynamics and intracellular signaling pathways.
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技术参数
- 靶点基因名
- PITPNB
- 蛋白别名
- phosphatidylinositol transfer protein beta; PITPNB
- UniProt
- P48739
- 物种
- Human
产品详情
- 靶点名称
- PITPNB
- 蛋白名称
- phosphatidylinositol transfer protein beta
- 蛋白别名
- Phosphatidylinositol transfer protein beta isoform; PI-TP-beta; PtdIns transfer protein beta; PtdInsTP beta
- 靶点基因名
- PITPNB
- UniProt
- P48739
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phosphatidylinositol transfer protein beta (PITPNB) is a cytosolic lipid-transfer protein that facilitates the movement of phosphatidylinositol (PI) and phosphatidylcholine (PC) between cellular membranes. It utilizes a hydrophobic cavity to shield individual lipids during transport, supporting phosphoinositide synthesis by delivering PI to specific PI kinases and phospholipases. PITPNB is a member of the SRPBCC superfamily and contains an N-terminal lipid-binding core that mediates membrane association and lipid exchange. By maintaining local phosphoinositide pools, it regulates phosphoinositide-dependent signaling, vesicular trafficking, and regulated exocytosis. While it shares functional similarities with PITP-alpha, PITPNB maintains distinct roles in coordinating membrane dynamics and intracellular signaling pathways.