抗人 PIM2 抗体对
01AB02003
Pim-2 proto-oncogene, serine/threonine kinase (PIM2) is a constitutively active cytoplasmic kinase that serves as a critical regulator of cell survival and proliferation. It functions by phosphorylating key substrates, including BAD, MYC, and 4E-BP1, thereby inhibiting apoptosis and enhancing cap-dependent translation through an mTORC1-independent pathway. PIM2 also supports NF-κB-dependent survival signaling and maintains mitochondrial potential, providing resistance to cytotoxic stimuli and growth factor withdrawal. Clinically, PIM2 is frequently overexpressed in various hematologic malignancies and solid tumors, where it acts as an oncogenic driver by promoting metabolic reprogramming, enhanced glycolysis, and sustained proliferative signaling.
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技术参数
- 靶点基因名
- PIM2
- 蛋白别名
- Pim-2 proto-oncogene, serine/threonine kinase; PIM2
- UniProt
- Q9P1W9
- 物种
- Human
产品详情
- 靶点名称
- PIM2
- 蛋白名称
- Pim-2 proto-oncogene, serine/threonine kinase
- 蛋白别名
- Serine/threonine-protein kinase pim-2; Pim-2h
- 靶点基因名
- PIM2
- UniProt
- Q9P1W9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Pim-2 proto-oncogene, serine/threonine kinase (PIM2) is a constitutively active cytoplasmic kinase that serves as a critical regulator of cell survival and proliferation. It functions by phosphorylating key substrates, including BAD, MYC, and 4E-BP1, thereby inhibiting apoptosis and enhancing cap-dependent translation through an mTORC1-independent pathway. PIM2 also supports NF-κB-dependent survival signaling and maintains mitochondrial potential, providing resistance to cytotoxic stimuli and growth factor withdrawal. Clinically, PIM2 is frequently overexpressed in various hematologic malignancies and solid tumors, where it acts as an oncogenic driver by promoting metabolic reprogramming, enhanced glycolysis, and sustained proliferative signaling.