人 PILRA 抗体对
01AB03428
Paired immunoglobin like type 2 receptor alpha (PILRA) is a type I transmembrane glycoprotein primarily expressed on myeloid cells, including microglia and macrophages. It functions as an inhibitory receptor that negatively regulates inflammatory responses through its intracellular immunoreceptor tyrosine-based inhibitory motif. PILRA recognizes and binds O-glycosylated ligands, such as complement component 4A and herpes simplex virus-1 glycoprotein B, via a sialic acid-binding pocket in its extracellular Ig-like domain. This interaction is crucial for modulating innate immune signaling and maintaining immune homeostasis. Clinically, the G78R genetic variant of PILRA is well-established as a protective factor against Alzheimer's disease, as it reduces ligand affinity and limits microglial inhibition. Additionally, PILRA serves as an entry receptor for HSV-1, and its dysregulation is linked to altered susceptibility to viral infections and inflammatory conditions, emphasizing its role as a key checkpoint in myeloid cell activation.
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技术参数
- 靶点基因名
- PILRA
- 蛋白别名
- paired immunoglobin like type 2 receptor alpha; PILRA
- UniProt
- Q9UKJ1
- 物种
- Human
产品详情
- 靶点名称
- PILRA
- 蛋白名称
- paired immunoglobin like type 2 receptor alpha
- 蛋白别名
- Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; Inhibitory receptor PILR-alpha
- 靶点基因名
- PILRA
- UniProt
- Q9UKJ1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Paired immunoglobin like type 2 receptor alpha (PILRA) is a type I transmembrane glycoprotein primarily expressed on myeloid cells, including microglia and macrophages. It functions as an inhibitory receptor that negatively regulates inflammatory responses through its intracellular immunoreceptor tyrosine-based inhibitory motif. PILRA recognizes and binds O-glycosylated ligands, such as complement component 4A and herpes simplex virus-1 glycoprotein B, via a sialic acid-binding pocket in its extracellular Ig-like domain. This interaction is crucial for modulating innate immune signaling and maintaining immune homeostasis. Clinically, the G78R genetic variant of PILRA is well-established as a protective factor against Alzheimer's disease, as it reduces ligand affinity and limits microglial inhibition. Additionally, PILRA serves as an entry receptor for HSV-1, and its dysregulation is linked to altered susceptibility to viral infections and inflammatory conditions, emphasizing its role as a key checkpoint in myeloid cell activation.