人 PIKFYVE 抗体对
01AB00338
Phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE) is an enzyme encoded by the PIKFYVE gene in humans, which plays a crucial role in phosphoinositide metabolism. It primarily phosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) to produce phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 5-phosphate (PtdIns5P). PIKFYVE is a large protein with multiple functional domains and is expressed in several spliced forms. Its enzymatic activity is essential for vesicular dynamics, affecting trafficking pathways through the endosomal system. Impaired PIKFYVE activity leads to lysosome enlargement and cytoplasmic vacuolation due to disrupted PtdIns(3,5)P2 synthesis and lysosome fission. Mutations in PIKFYVE are associated with Francois-Neetens corneal fleck dystrophy and have been implicated in pathogen invasion, including HIV and Salmonella replication, as well as type 2 diabetes through the inhibition of insulin-regulated glucose uptake. PIKFYVE also interacts with other proteins to form a complex that tightly controls PtdIns(3,5)P2 levels, highlighting its importance in cellular processes.
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技术参数
- 靶点基因名
- PIKFYVE
- 基因别名
- KIAA0981; PIP5K3
- 蛋白别名
- phosphoinositide kinase, FYVE-type zinc finger containing; PIKFYVE
- UniProt
- Q9Y2I7
- 物种
- Human
产品详情
- 靶点名称
- PIKFYVE
- 蛋白名称
- phosphoinositide kinase, FYVE-type zinc finger containing
- 蛋白别名
- 1-phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase; FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type III PIP kinase; Serine-protein kinase PIKFYVE
- 靶点基因名
- PIKFYVE
- 基因别名
- KIAA0981; PIP5K3
- UniProt
- Q9Y2I7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE) is an enzyme encoded by the PIKFYVE gene in humans, which plays a crucial role in phosphoinositide metabolism. It primarily phosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) to produce phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 5-phosphate (PtdIns5P). PIKFYVE is a large protein with multiple functional domains and is expressed in several spliced forms. Its enzymatic activity is essential for vesicular dynamics, affecting trafficking pathways through the endosomal system. Impaired PIKFYVE activity leads to lysosome enlargement and cytoplasmic vacuolation due to disrupted PtdIns(3,5)P2 synthesis and lysosome fission. Mutations in PIKFYVE are associated with Francois-Neetens corneal fleck dystrophy and have been implicated in pathogen invasion, including HIV and Salmonella replication, as well as type 2 diabetes through the inhibition of insulin-regulated glucose uptake. PIKFYVE also interacts with other proteins to form a complex that tightly controls PtdIns(3,5)P2 levels, highlighting its importance in cellular processes.