人 PIK3AP1 抗体对
01AB03443
Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) is a crucial adaptor protein that plays an essential role in the signaling pathways of phosphatidylinositol 3-kinase (PI3K), particularly in immune cells. It contains several functional domains that facilitate interactions with various proteins involved in immune responses, including receptors and kinases. PIK3AP1 is involved in regulating cell survival, proliferation, and differentiation, particularly in lymphocytes, where it modulates signaling from the B-cell receptor and other surface receptors. Dysregulation of PIK3AP1 has been linked to various diseases, notably autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, where altered signaling can lead to inappropriate immune activation and inflammation. Additionally, PIK3AP1 has been implicated in cancer biology; its expression levels can influence tumor growth and metastasis by affecting the PI3K/Akt signaling pathway.
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技术参数
- 靶点基因名
- PIK3AP1
- 基因别名
- BCAP
- 蛋白别名
- phosphoinositide-3-kinase adaptor protein 1; PIK3AP1
- UniProt
- Q6ZUJ8
- 物种
- Human
产品详情
- 靶点名称
- PIK3AP1
- 蛋白名称
- phosphoinositide-3-kinase adaptor protein 1
- 蛋白别名
- Phosphoinositide 3-kinase adapter protein 1; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1
- 靶点基因名
- PIK3AP1
- 基因别名
- BCAP
- UniProt
- Q6ZUJ8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) is a crucial adaptor protein that plays an essential role in the signaling pathways of phosphatidylinositol 3-kinase (PI3K), particularly in immune cells. It contains several functional domains that facilitate interactions with various proteins involved in immune responses, including receptors and kinases. PIK3AP1 is involved in regulating cell survival, proliferation, and differentiation, particularly in lymphocytes, where it modulates signaling from the B-cell receptor and other surface receptors. Dysregulation of PIK3AP1 has been linked to various diseases, notably autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, where altered signaling can lead to inappropriate immune activation and inflammation. Additionally, PIK3AP1 has been implicated in cancer biology; its expression levels can influence tumor growth and metastasis by affecting the PI3K/Akt signaling pathway.