人 PIGR 抗体对
01AB01293
Polymeric immunoglobulin receptor (PIGR) is a transmembrane glycoprotein critical for mucosal immunity. Encoded by the PIGR gene, it facilitates the transcytosis of polymeric immunoglobulins A (IgA) and M (IgM) across epithelial cells. PIGR consists of five extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail. It binds to dimeric IgA or pentameric IgM at the basolateral surface of epithelial cells, internalizes the complex, and transports it to the apical membrane. Upon release, the extracellular domain of PIGR (called the secretory component) remains attached to IgA/IgM, forming secretory immunoglobulins (sIgA/sIgM) that protect mucosal surfaces from pathogens. Dysregulation of PIGR is linked to diseases such as inflammatory bowel disease (IBD) and chronic rhinosinusitis, where reduced expression compromises mucosal defense. Additionally, aberrant PIGR expression is observed in cancers, including colorectal and hepatocellular carcinomas, correlating with tumor progression and immune evasion. Genetic variants in PIGR may also predispose individuals to autoimmune disorders like systemic lupus erythematosus.
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技术参数
- 靶点基因名
- PIGR
- 蛋白别名
- polymeric immunoglobulin receptor; PIGR
- UniProt
- P01833
- 物种
- Human
产品详情
- 靶点名称
- PIGR
- 蛋白名称
- polymeric immunoglobulin receptor
- 蛋白别名
- Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor; Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]
- 靶点基因名
- PIGR
- UniProt
- P01833
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Polymeric immunoglobulin receptor (PIGR) is a transmembrane glycoprotein critical for mucosal immunity. Encoded by the PIGR gene, it facilitates the transcytosis of polymeric immunoglobulins A (IgA) and M (IgM) across epithelial cells. PIGR consists of five extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail. It binds to dimeric IgA or pentameric IgM at the basolateral surface of epithelial cells, internalizes the complex, and transports it to the apical membrane. Upon release, the extracellular domain of PIGR (called the secretory component) remains attached to IgA/IgM, forming secretory immunoglobulins (sIgA/sIgM) that protect mucosal surfaces from pathogens. Dysregulation of PIGR is linked to diseases such as inflammatory bowel disease (IBD) and chronic rhinosinusitis, where reduced expression compromises mucosal defense. Additionally, aberrant PIGR expression is observed in cancers, including colorectal and hepatocellular carcinomas, correlating with tumor progression and immune evasion. Genetic variants in PIGR may also predispose individuals to autoimmune disorders like systemic lupus erythematosus.