人 PIBF1 抗体对
01AB02867
Progesterone immunomodulatory binding factor 1 (PIBF1, also known as CEP90/C13orf24) is a multifunctional protein with distinct intracellular and secreted roles. The intracellular isoform localizes to the pericentriolar material, where it is essential for centriole duplication, mitotic spindle integrity, and ciliogenesis by recruiting key centrosomal proteins. Conversely, the secreted isoform acts as a critical mediator of progesterone signaling during pregnancy, modulating arachidonic acid metabolism and shifting immunity toward a Th2 profile via JAK/STAT signaling to prevent fetal rejection. Biallelic loss-of-function variants in PIBF1 are associated with autosomal recessive ciliopathies, including Joubert syndrome 33, highlighting its importance in developmental pathways.
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技术参数
- 靶点基因名
- PIBF1
- 基因别名
- C13orf24; PIBF
- 蛋白别名
- progesterone immunomodulatory binding factor 1; PIBF1
- UniProt
- Q8WXW3
- 物种
- Human
产品详情
- 靶点名称
- PIBF1
- 蛋白名称
- progesterone immunomodulatory binding factor 1
- 蛋白别名
- Progesterone-induced-blocking factor 1; PIBF; Centrosomal protein of 90 kDa; CEP90
- 靶点基因名
- PIBF1
- 基因别名
- C13orf24; PIBF
- UniProt
- Q8WXW3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Progesterone immunomodulatory binding factor 1 (PIBF1, also known as CEP90/C13orf24) is a multifunctional protein with distinct intracellular and secreted roles. The intracellular isoform localizes to the pericentriolar material, where it is essential for centriole duplication, mitotic spindle integrity, and ciliogenesis by recruiting key centrosomal proteins. Conversely, the secreted isoform acts as a critical mediator of progesterone signaling during pregnancy, modulating arachidonic acid metabolism and shifting immunity toward a Th2 profile via JAK/STAT signaling to prevent fetal rejection. Biallelic loss-of-function variants in PIBF1 are associated with autosomal recessive ciliopathies, including Joubert syndrome 33, highlighting its importance in developmental pathways.