人 PHLPP1 抗体对
01AB02252
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a magnesium/manganese-dependent serine/threonine phosphatase that serves as a critical regulator of cell signaling. It specifically dephosphorylates the hydrophobic motif of various AGC kinases, including Akt2/3, PKC alpha/beta, and S6K1, as well as nuclear substrates like STAT1 and histones. By inactivating these targets, PHLPP1 functions as a broad tumor suppressor that dampens the PI3K-Akt and RAS-ERK pathways, thereby limiting cell proliferation and promoting apoptosis. It also modulates metabolic and immune signaling through the repression of receptor tyrosine kinase transcription. Clinically, the loss or dysregulation of PHLPP1 is linked to multiple cancers, including prostate and hematologic malignancies, and is associated with the development of obesity and type 2 diabetes due to impaired insulin signaling.
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技术参数
- 靶点基因名
- PHLPP1
- 基因别名
- KIAA0606; PHLPP; PLEKHE1; SCOP
- 蛋白别名
- PH domain and leucine rich repeat protein phosphatase 1; PHLPP1
- UniProt
- O60346
- 物种
- Human
产品详情
- 靶点名称
- PHLPP1
- 蛋白名称
- PH domain and leucine rich repeat protein phosphatase 1
- 蛋白别名
- PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein; hSCOP
- 靶点基因名
- PHLPP1
- 基因别名
- KIAA0606; PHLPP; PLEKHE1; SCOP
- UniProt
- O60346
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a magnesium/manganese-dependent serine/threonine phosphatase that serves as a critical regulator of cell signaling. It specifically dephosphorylates the hydrophobic motif of various AGC kinases, including Akt2/3, PKC alpha/beta, and S6K1, as well as nuclear substrates like STAT1 and histones. By inactivating these targets, PHLPP1 functions as a broad tumor suppressor that dampens the PI3K-Akt and RAS-ERK pathways, thereby limiting cell proliferation and promoting apoptosis. It also modulates metabolic and immune signaling through the repression of receptor tyrosine kinase transcription. Clinically, the loss or dysregulation of PHLPP1 is linked to multiple cancers, including prostate and hematologic malignancies, and is associated with the development of obesity and type 2 diabetes due to impaired insulin signaling.