人 PHF10 抗体对
01AB03160
PHD finger protein 10 (PHF10), also known as BAF45A, is a nuclear component of the neural progenitor-specific BAF (npBAF) chromatin-remodeling complex. Containing two PHD zinc-finger domains, it regulates transcription and chromatin structure essential for the proliferation and self-renewal of neural progenitor cells. As neurons differentiate, PHF10 is replaced by homologous subunits in the nBAF complex. It also participates in DNA damage responses and homologous recombination. Clinically, PHF10 dysfunction is associated with intellectual developmental disorders and chromosome 6q deletion syndromes, while its overexpression supports cell proliferation in various cancers.
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技术参数
- 靶点基因名
- PHF10
- 基因别名
- BAF45A
- 蛋白别名
- PHD finger protein 10; PHF10
- UniProt
- Q8WUB8
- 物种
- Human
产品详情
- 靶点名称
- PHF10
- 蛋白名称
- PHD finger protein 10
- 蛋白别名
- PHD finger protein 10; BRG1-associated factor 45a; BAF45a; XAP135
- 靶点基因名
- PHF10
- 基因别名
- BAF45A
- UniProt
- Q8WUB8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
PHD finger protein 10 (PHF10), also known as BAF45A, is a nuclear component of the neural progenitor-specific BAF (npBAF) chromatin-remodeling complex. Containing two PHD zinc-finger domains, it regulates transcription and chromatin structure essential for the proliferation and self-renewal of neural progenitor cells. As neurons differentiate, PHF10 is replaced by homologous subunits in the nBAF complex. It also participates in DNA damage responses and homologous recombination. Clinically, PHF10 dysfunction is associated with intellectual developmental disorders and chromosome 6q deletion syndromes, while its overexpression supports cell proliferation in various cancers.