人 PHD2 抗体对
01AB01683
Egl-9 family hypoxia inducible factor 1 (PHD2) is the primary cellular oxygen sensor and a prolyl-4-hydroxylase that regulates the stability of hypoxia-inducible factor (HIF). As a non-heme Fe(II) and 2-oxoglutarate-dependent dioxygenase, PHD2 hydroxylates specific proline residues on HIF-alpha under normoxic conditions, leading to its recognition by pVHL and subsequent proteasomal degradation. Under oxidative stress or hypoxia, PHD2 activity is reduced, allowing HIF-alpha to stabilize and initiate adaptive transcriptional programs. Clinically, germline mutations in the EGLN1 gene encoding PHD2 are a well-established cause of familial erythrocytosis due to inappropriate HIF activation and elevated erythropoietin levels. Additionally, altered PHD2 signaling is implicated in the pathogenesis of cancer, angiogenesis, and various ischemic and cardiovascular diseases.
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技术参数
- 靶点基因名
- EGLN1
- 基因别名
- C1orf12
- 蛋白别名
- egl-9 family hypoxia inducible factor 1; PHD2
- UniProt
- Q9GZT9
- 物种
- Human
产品详情
- 靶点名称
- PHD2
- 蛋白名称
- egl-9 family hypoxia inducible factor 1
- 蛋白别名
- Egl nine homolog 1; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; SM-20
- 靶点基因名
- EGLN1
- 基因别名
- C1orf12
- UniProt
- Q9GZT9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Egl-9 family hypoxia inducible factor 1 (PHD2) is the primary cellular oxygen sensor and a prolyl-4-hydroxylase that regulates the stability of hypoxia-inducible factor (HIF). As a non-heme Fe(II) and 2-oxoglutarate-dependent dioxygenase, PHD2 hydroxylates specific proline residues on HIF-alpha under normoxic conditions, leading to its recognition by pVHL and subsequent proteasomal degradation. Under oxidative stress or hypoxia, PHD2 activity is reduced, allowing HIF-alpha to stabilize and initiate adaptive transcriptional programs. Clinically, germline mutations in the EGLN1 gene encoding PHD2 are a well-established cause of familial erythrocytosis due to inappropriate HIF activation and elevated erythropoietin levels. Additionally, altered PHD2 signaling is implicated in the pathogenesis of cancer, angiogenesis, and various ischemic and cardiovascular diseases.