人 PGF 抗体对
01AB01285
Placental growth factor (PGF) is a member of the vascular endothelial growth factor (VEGF) family, primarily involved in angiogenesis and vasculogenesis during embryonic development. PGF is predominantly produced by placental trophoblast cells, facilitating proper blood vessel formation to support fetal growth. It is also expressed in various tissues, including the heart, lungs, and skeletal muscle, albeit at lower levels. Dysregulation of PGF has been linked to several diseases, particularly preeclampsia, where altered serum levels of PGF and soluble fms-like tyrosine kinase-1 (sFlt-1) are observed, indicating potential placental insufficiency. Additionally, PGF is associated with atherosclerosis, contributing to plaque inflammation and neovascularization, which can lead to cardiovascular complications.
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技术参数
- 靶点基因名
- PGF
- 蛋白别名
- Placenta growth factor; PGF
- UniProt
- P49763-2
- 物种
- Human
产品详情
- 靶点名称
- PGF
- 蛋白名称
- Placenta growth factor
- 靶点基因名
- PGF
- UniProt
- P49763-2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Placental growth factor (PGF) is a member of the vascular endothelial growth factor (VEGF) family, primarily involved in angiogenesis and vasculogenesis during embryonic development. PGF is predominantly produced by placental trophoblast cells, facilitating proper blood vessel formation to support fetal growth. It is also expressed in various tissues, including the heart, lungs, and skeletal muscle, albeit at lower levels. Dysregulation of PGF has been linked to several diseases, particularly preeclampsia, where altered serum levels of PGF and soluble fms-like tyrosine kinase-1 (sFlt-1) are observed, indicating potential placental insufficiency. Additionally, PGF is associated with atherosclerosis, contributing to plaque inflammation and neovascularization, which can lead to cardiovascular complications.