人 Peroxiredoxin-5 抗体对
01AB03504
Peroxiredoxin-5 (PRDX5) is a member of the peroxiredoxin family, functioning primarily as an antioxidant enzyme that reduces peroxides and regulates cellular redox status. This mitochondrial protein contains a peroxidatic cysteine residue, which plays a critical role in its enzymatic activity, enabling it to detoxify reactive oxygen species (ROS). PRDX5 is unique among peroxiredoxins due to its ability to form intramolecular disulfide bonds, which are essential for its catalytic function. Dysregulation of PRDX5 has been implicated in various diseases, particularly neurodegenerative disorders and cancer. For instance, decreased expression of PRDX5 has been associated with increased oxidative stress and neuronal apoptosis in conditions like Alzheimer’s disease. In cancer, altered levels of PRDX5 can influence tumor progression and resistance to therapy by modulating the oxidative environment within cells.
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技术参数
- 靶点基因名
- PRDX5
- 基因别名
- ACR1
- 蛋白别名
- peroxiredoxin 5; Peroxiredoxin-5
- UniProt
- P30044
- 物种
- Human
产品详情
- 靶点名称
- Peroxiredoxin-5
- 蛋白名称
- peroxiredoxin 5
- 蛋白别名
- Peroxiredoxin-5; mitochondrial; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin-dependent peroxiredoxin 5
- 靶点基因名
- PRDX5
- 基因别名
- ACR1
- UniProt
- P30044
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Peroxiredoxin-5 (PRDX5) is a member of the peroxiredoxin family, functioning primarily as an antioxidant enzyme that reduces peroxides and regulates cellular redox status. This mitochondrial protein contains a peroxidatic cysteine residue, which plays a critical role in its enzymatic activity, enabling it to detoxify reactive oxygen species (ROS). PRDX5 is unique among peroxiredoxins due to its ability to form intramolecular disulfide bonds, which are essential for its catalytic function. Dysregulation of PRDX5 has been implicated in various diseases, particularly neurodegenerative disorders and cancer. For instance, decreased expression of PRDX5 has been associated with increased oxidative stress and neuronal apoptosis in conditions like Alzheimer’s disease. In cancer, altered levels of PRDX5 can influence tumor progression and resistance to therapy by modulating the oxidative environment within cells.