人过氧化物还原酶-1 抗体对
01AB03477
Peroxiredoxin 1 (Peroxiredoxin-1) is a cytosolic antioxidant enzyme that plays a central role in maintaining cellular redox homeostasis by catalyzing the thioredoxin-dependent reduction of hydrogen peroxide and alkyl hydroperoxides. Beyond its scavenger function, it acts as a molecular sensor for hydrogen peroxide in various signaling pathways, modulating cell proliferation, differentiation, and immune responses. It is particularly involved in signaling downstream of growth factors and TNF-alpha. Peroxiredoxin-1 is constitutively expressed in most tissues and is further induced by oxidative stress. Clinically, the protein is frequently dysregulated in multiple malignancies, including pancreatic, esophageal, and lung cancers, where it can act as either a tumor suppressor or an oncogenic driver depending on the cellular context.
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技术参数
- 靶点基因名
- PRDX1
- 基因别名
- PAGA; PAGB; TDPX2
- 蛋白别名
- peroxiredoxin 1; Peroxiredoxin-1
- UniProt
- Q06830
- 物种
- Human
产品详情
- 靶点名称
- Peroxiredoxin-1
- 蛋白名称
- peroxiredoxin 1
- 蛋白别名
- Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; Thioredoxin-dependent peroxiredoxin 1
- 靶点基因名
- PRDX1
- 基因别名
- PAGA; PAGB; TDPX2
- UniProt
- Q06830
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Peroxiredoxin 1 (Peroxiredoxin-1) is a cytosolic antioxidant enzyme that plays a central role in maintaining cellular redox homeostasis by catalyzing the thioredoxin-dependent reduction of hydrogen peroxide and alkyl hydroperoxides. Beyond its scavenger function, it acts as a molecular sensor for hydrogen peroxide in various signaling pathways, modulating cell proliferation, differentiation, and immune responses. It is particularly involved in signaling downstream of growth factors and TNF-alpha. Peroxiredoxin-1 is constitutively expressed in most tissues and is further induced by oxidative stress. Clinically, the protein is frequently dysregulated in multiple malignancies, including pancreatic, esophageal, and lung cancers, where it can act as either a tumor suppressor or an oncogenic driver depending on the cellular context.