人 Periostin 抗体对
01AB01922
POSTN (periostin) is a matricellular protein that plays diverse roles in both physiological and pathological processes. It is involved in embryonic development, tissue repair, and maintenance of bone and connective tissues. However, abnormal upregulation of POSTN is associated with various diseases, particularly cancer and inflammatory conditions. In cancer, POSTN promotes tumor progression by enhancing cell proliferation, invasion, and metastasis through interactions with integrins and activation of signaling pathways like MAPK and PI3K/AKT. It also contributes to the tumor microenvironment by promoting angiogenesis and fibrosis. In inflammatory diseases such as asthma and fibrosis, POSTN interacts with cytokines and activates pathways like NF-κB, exacerbating inflammation and tissue remodeling. Additionally, POSTN has been implicated in cardiovascular diseases and intervertebral disc degeneration. Its multifaceted roles in disease progression make POSTN a potential biomarker and therapeutic target for various conditions.
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技术参数
- 靶点基因名
- POSTN
- 基因别名
- OSF2
- 蛋白别名
- periostin; Periostin
- UniProt
- Q15063
- 物种
- Human
产品详情
- 靶点名称
- Periostin
- 蛋白名称
- periostin
- 蛋白别名
- Periostin; PN; Osteoblast-specific factor 2; OSF-2
- 靶点基因名
- POSTN
- 基因别名
- OSF2
- UniProt
- Q15063
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
POSTN (periostin) is a matricellular protein that plays diverse roles in both physiological and pathological processes. It is involved in embryonic development, tissue repair, and maintenance of bone and connective tissues. However, abnormal upregulation of POSTN is associated with various diseases, particularly cancer and inflammatory conditions. In cancer, POSTN promotes tumor progression by enhancing cell proliferation, invasion, and metastasis through interactions with integrins and activation of signaling pathways like MAPK and PI3K/AKT. It also contributes to the tumor microenvironment by promoting angiogenesis and fibrosis. In inflammatory diseases such as asthma and fibrosis, POSTN interacts with cytokines and activates pathways like NF-κB, exacerbating inflammation and tissue remodeling. Additionally, POSTN has been implicated in cardiovascular diseases and intervertebral disc degeneration. Its multifaceted roles in disease progression make POSTN a potential biomarker and therapeutic target for various conditions.