人 PEBP4 抗体对
01AB02864
Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted, glycosylated member of the evolutionarily conserved PEBP family. It localizes to lysosomes and perinuclear regions and can translocate to the plasma membrane upon stimulation by TNFα. Functionally, PEBP4 binds phosphatidylethanolamine and interacts with Raf-1 and MEK to modulate the MAPK and PI3K-AKT signaling pathways. It acts as a pro-survival factor; its overexpression enhances the phosphorylation of ERK, JNK, and AKT, thereby promoting cell survival and resistance to apoptosis. Clinically, PEBP4 is frequently overexpressed in multiple cancers and is associated with tumor progression and poor prognosis. Its role in inhibiting TNFα- and TRAIL-induced apoptosis makes it a significant oncogenic factor and a potential biomarker or therapeutic target in oncology.
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技术参数
- 靶点基因名
- PEBP4
- 基因别名
- CORK1
- 蛋白别名
- phosphatidylethanolamine binding protein 4; PEBP4
- UniProt
- Q96S96
- 物种
- Human
产品详情
- 靶点名称
- PEBP4
- 蛋白名称
- phosphatidylethanolamine binding protein 4
- 蛋白别名
- Phosphatidylethanolamine-binding protein 4; PEBP-4; hPEBP4; Protein cousin-of-RKIP 1
- 靶点基因名
- PEBP4
- 基因别名
- CORK1
- UniProt
- Q96S96
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted, glycosylated member of the evolutionarily conserved PEBP family. It localizes to lysosomes and perinuclear regions and can translocate to the plasma membrane upon stimulation by TNFα. Functionally, PEBP4 binds phosphatidylethanolamine and interacts with Raf-1 and MEK to modulate the MAPK and PI3K-AKT signaling pathways. It acts as a pro-survival factor; its overexpression enhances the phosphorylation of ERK, JNK, and AKT, thereby promoting cell survival and resistance to apoptosis. Clinically, PEBP4 is frequently overexpressed in multiple cancers and is associated with tumor progression and poor prognosis. Its role in inhibiting TNFα- and TRAIL-induced apoptosis makes it a significant oncogenic factor and a potential biomarker or therapeutic target in oncology.