人 PDGFD 抗体对
01AB03899
Platelet-derived growth factor D (PDGFD) is a member of the platelet-derived growth factor (PDGF) family, which consists of mitogenic factors that primarily stimulate cells of mesenchymal origin. PDGFD is characterized by its ability to form homodimers and is distinguished by an unusual N-terminal CUB domain, which is not present in other PDGF family members. This protein plays a critical role in various physiological processes, including cell proliferation, migration, and angiogenesis. Dysregulation of PDGFD has been implicated in several diseases, particularly in cancer and fibrosis. For example, elevated levels of PDGFD have been associated with tumor progression and metastasis in various cancers, including breast and prostate cancer, where it promotes angiogenesis and the proliferation of cancer-associated fibroblasts. Additionally, PDGFD has been linked to fibrotic diseases, as it can stimulate excessive extracellular matrix production.
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技术参数
- 靶点基因名
- PDGFD
- 基因别名
- IEGF; SCDGFB
- 蛋白别名
- platelet derived growth factor D; PDGFD
- UniProt
- Q9GZP0
- 物种
- Human
产品详情
- 靶点名称
- PDGFD
- 蛋白名称
- platelet derived growth factor D
- 蛋白别名
- Platelet-derived growth factor D; PDGF-D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B) [Cleaved into: Platelet-derived growth factor D; latent form; PDGFD latent form; Platelet-derived growth factor D; receptor-binding form; PDGFD receptor-binding form]
- 靶点基因名
- PDGFD
- 基因别名
- IEGF; SCDGFB
- UniProt
- Q9GZP0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Platelet-derived growth factor D (PDGFD) is a member of the platelet-derived growth factor (PDGF) family, which consists of mitogenic factors that primarily stimulate cells of mesenchymal origin. PDGFD is characterized by its ability to form homodimers and is distinguished by an unusual N-terminal CUB domain, which is not present in other PDGF family members. This protein plays a critical role in various physiological processes, including cell proliferation, migration, and angiogenesis. Dysregulation of PDGFD has been implicated in several diseases, particularly in cancer and fibrosis. For example, elevated levels of PDGFD have been associated with tumor progression and metastasis in various cancers, including breast and prostate cancer, where it promotes angiogenesis and the proliferation of cancer-associated fibroblasts. Additionally, PDGFD has been linked to fibrotic diseases, as it can stimulate excessive extracellular matrix production.