人 PDGFB 抗体对
01AB01547
Platelet derived growth factor subunit B (PDGFB) is a secreted growth factor that plays a central role in mesenchymal cell proliferation, angiogenesis, and embryonic development. It functions as either a homodimer (PDGF-BB) or a heterodimer with PDGFA (PDGF-AB), signaling through the PDGFR-alpha and PDGFR-beta tyrosine kinase receptors. These interactions are critical for pericyte recruitment and vascular stability. Clinically, PDGFB is well-established in the pathogenesis of several disorders. Chromosomal rearrangements resulting in the COL1A1-PDGFB fusion drive constitutive autocrine signaling in dermatofibrosarcoma protuberans. Furthermore, dysregulated PDGFB signaling is a known cause of primary familial brain calcification, a condition characterized by abnormal calcium deposits in the brain vasculature and pericytes.
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技术参数
- 靶点基因名
- PDGFB
- 基因别名
- PDGF2; SIS
- 蛋白别名
- platelet derived growth factor subunit B; PDGFB
- UniProt
- P01127
- 物种
- Human
产品详情
- 靶点名称
- PDGFB
- 蛋白名称
- platelet derived growth factor subunit B
- 蛋白别名
- Platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; Becaplermin
- 靶点基因名
- PDGFB
- 基因别名
- PDGF2; SIS
- UniProt
- P01127
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Platelet derived growth factor subunit B (PDGFB) is a secreted growth factor that plays a central role in mesenchymal cell proliferation, angiogenesis, and embryonic development. It functions as either a homodimer (PDGF-BB) or a heterodimer with PDGFA (PDGF-AB), signaling through the PDGFR-alpha and PDGFR-beta tyrosine kinase receptors. These interactions are critical for pericyte recruitment and vascular stability. Clinically, PDGFB is well-established in the pathogenesis of several disorders. Chromosomal rearrangements resulting in the COL1A1-PDGFB fusion drive constitutive autocrine signaling in dermatofibrosarcoma protuberans. Furthermore, dysregulated PDGFB signaling is a known cause of primary familial brain calcification, a condition characterized by abnormal calcium deposits in the brain vasculature and pericytes.