人 PDGFA 抗体对
01AB00337
Platelet-derived growth factor subunit A (PDGFA) is a key protein involved in various cellular processes, including cell proliferation, migration, and survival. It belongs to the platelet-derived growth factor family and can form homodimers or heterodimers with PDGF subunit B, facilitating its role as a potent mitogen for mesenchymal cells. PDGFA signaling is crucial during embryonic development and tissue homeostasis, but dysregulation can lead to several diseases. Notably, mutations in the PDGFA gene are implicated in conditions such as chronic eosinophilic leukemia and gastrointestinal stromal tumors (GISTs), where constitutive activation of PDGFA promotes uncontrolled cell growth and tumor formation. Additionally, PDGFA mutations are associated with inflammatory fibroid polyps, benign tumors that arise from excessive cell proliferation in the gastrointestinal tract.
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技术参数
- 靶点基因名
- PDGFA
- 基因别名
- PDGF1
- 蛋白别名
- platelet derived growth factor subunit A; PDGFA
- UniProt
- P04085
- 物种
- Human
产品详情
- 靶点名称
- PDGFA
- 蛋白名称
- platelet derived growth factor subunit A
- 蛋白别名
- Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
- 靶点基因名
- PDGFA
- 基因别名
- PDGF1
- UniProt
- P04085
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Platelet-derived growth factor subunit A (PDGFA) is a key protein involved in various cellular processes, including cell proliferation, migration, and survival. It belongs to the platelet-derived growth factor family and can form homodimers or heterodimers with PDGF subunit B, facilitating its role as a potent mitogen for mesenchymal cells. PDGFA signaling is crucial during embryonic development and tissue homeostasis, but dysregulation can lead to several diseases. Notably, mutations in the PDGFA gene are implicated in conditions such as chronic eosinophilic leukemia and gastrointestinal stromal tumors (GISTs), where constitutive activation of PDGFA promotes uncontrolled cell growth and tumor formation. Additionally, PDGFA mutations are associated with inflammatory fibroid polyps, benign tumors that arise from excessive cell proliferation in the gastrointestinal tract.