人 PDE4D 抗体对
01AB04128
Phosphodiesterase 4D (PDE4D) is a member of the phosphodiesterase family that plays a critical role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a vital secondary messenger involved in various physiological processes including cognitive functions, inflammation, and cardiac signaling. PDE4D is implicated in several diseases; notably, it has been linked to neurodegenerative disorders such as Alzheimer’s disease and fragile X syndrome, where its dysfunction contributes to cognitive impairment. Additionally, mutations in PDE4D are associated with acrodysostosis type 2, characterized by intellectual disabilities and skeletal dysmorphologies. The enzyme's activity can be modulated through various mechanisms, including phosphorylation and dimerization, which affect its hydrolytic function on cAMP. Furthermore, PDE4D is being explored as a pharmacological target for treating conditions like cancer and inflammatory diseases due to its oncogenic properties and involvement in immune responses.
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技术参数
- 靶点基因名
- PDE4D
- 基因别名
- DPDE3
- 蛋白别名
- phosphodiesterase 4D; PDE4D
- UniProt
- Q08499
- 物种
- Human
产品详情
- 靶点名称
- PDE4D
- 蛋白名称
- phosphodiesterase 4D
- 蛋白别名
- cAMP-specific 3'; 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43
- 靶点基因名
- PDE4D
- 基因别名
- DPDE3
- UniProt
- Q08499
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phosphodiesterase 4D (PDE4D) is a member of the phosphodiesterase family that plays a critical role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a vital secondary messenger involved in various physiological processes including cognitive functions, inflammation, and cardiac signaling. PDE4D is implicated in several diseases; notably, it has been linked to neurodegenerative disorders such as Alzheimer’s disease and fragile X syndrome, where its dysfunction contributes to cognitive impairment. Additionally, mutations in PDE4D are associated with acrodysostosis type 2, characterized by intellectual disabilities and skeletal dysmorphologies. The enzyme's activity can be modulated through various mechanisms, including phosphorylation and dimerization, which affect its hydrolytic function on cAMP. Furthermore, PDE4D is being explored as a pharmacological target for treating conditions like cancer and inflammatory diseases due to its oncogenic properties and involvement in immune responses.